Universität zu Köln

Dietlein, Markus, Kobe, Carsten, Kuhnert, Georg, Stockter, Simone, Fischer, Thomas, Schomaecker, Klaus, Schmidt, Matthias, Dietlein, Felix, Zlatopolskiy, Boris D., Krapf, Philipp, Richarz, Raphael, Neubauer, Stephan, Drzezga, Alexander and Neumaier, Bernd ORCID: 0000-0001-5425-3116 (2015). Comparison of [F-18]DCFPyL and [Ga-68]Ga-PSMA-HBED-CC for PSMA-PET Imaging in Patients with Relapsed Prostate Cancer. Mol. Imaging. Biol., 17 (4). S. 575 - 585. NEW YORK: SPRINGER. ISSN 1860-2002

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Abstract

Gallium-68 (Ga-68)-labeled tracers for imaging expression of the prostate-specific membrane antigen (PSMA) such as the [Ga-68]Ga-PSMA-HBED-CC have already demonstrated high potential for the detection of recurrent prostate cancer. However, compared to Ga-68, a labeling with fluorine-18 (F-18) would offer advantages with respect to availability, production amount, and image resolution. [F-18]DCFPyL is a promising F-18-labeled candidate for PSMA-positron emission tomography (PET) imaging that has been recently introduced. In the current study, we aimed to compare [Ga-68]Ga-PSMA-HBED-CC and [F-18]DCFPyL for clinical use in biochemically relapsed prostate cancer. In 14 selected patients with PSA relapse of prostate cancer, [F-18]DCFPyL PET/X-ray computed tomography (CT) was performed in addition to [Ga-68]Ga-PSMA-HBED-CC PET/CT. A systematic comparison was carried out between results obtained with both tracers with regard to the number of detected PSMA-positive lesions, the standardized uptake value (SUV)(max) and the lesion to background ratios. All suspicious lesions identified by [Ga-68]Ga-PSMA-HBED-CC were also detected with [F-18]DCFPyL. In three patients, additional lesions were observed using [F-18]DCFPyL PET/CT. The mean SUVmax in the concordant [F-18]DCFPyL PSMA-positive lesions was significantly higher as compared to [Ga-68]Ga-PSMA-HBED-CC (14.5 vs. 12.2, p = 0.028, n = 15). The mean tumor to background ratios (n = 15) were significantly higher for [F-18]DCFPyL compared to [Ga-68]Ga-PSMA-HBED-CC using kidney, spleen, or parotid as reference organs (p = 0.006, p = 0.002, p = 0.008), but no significant differences were found using the liver (p = 0.167) or the mediastinum (p = 0.363) as reference organs. [F-18]DCFPyL PET/CT provided a high image quality and visualized small prostate lesions with excellent sensitivity. [F-18]DCFPyL represents a highly promising alternative to [Ga-68]Ga-PSMA-HBED-CC for PSMA-PET/CT imaging in relapsed prostate cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dietlein, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobe, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhnert, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Stockter, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schomaecker, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Zlatopolskiy, Boris D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krapf, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Richarz, Raphael UNSPECIFIED UNSPECIFIED UNSPECIFIED Neubauer, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-398399
DOI:	10.1007/s11307-015-0866-0
Journal or Publication Title:	Mol. Imaging. Biol.
Volume:	17
Number:	4
Page Range:	S. 575 - 585
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1860-2002
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMBRANE ANTIGEN-EXPRESSION; BIOCHEMICAL RECURRENCE; C-11-CHOLINE PET/CT; DIAGNOSIS; LIGAND; INHIBITOR; THERAPY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39839