Kelly, Steven ORCID: 0000-0001-8583-5362, Greenman, Chris, Cook, Peter R. and Papantonis, Argyris ORCID: 0000-0001-7551-1073 (2015). Exon Skipping Is Correlated with Exon Circularization. J. Mol. Biol., 427 (15). S. 2414 - 2418. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1089-8638

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Abstract

Circular RNAs are found in a wide range of organisms and it has been proposed that they perform disparate functions. However, how RNA circularization is connected to alternative splicing remains largely unexplored. Here, we stimulated primary human endothelial cells with tumor necrosis factor a or tumor growth factor 13, purified RNA, generated >2.4 billion RNA-seq reads, and used a custom pipeline to characterize circular RNAs derived from coding exons. We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kelly, StevenUNSPECIFIEDorcid.org/0000-0001-8583-5362UNSPECIFIED
Greenman, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cook, Peter R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papantonis, ArgyrisUNSPECIFIEDorcid.org/0000-0001-7551-1073UNSPECIFIED
URN: urn:nbn:de:hbz:38-398605
DOI: 10.1016/j.jmb.2015.02.018
Journal or Publication Title: J. Mol. Biol.
Volume: 427
Number: 15
Page Range: S. 2414 - 2418
Date: 2015
Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication: LONDON
ISSN: 1089-8638
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RNASMultiple languages
Biochemistry & Molecular BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39860

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