Universität zu Köln

Becker, Benjamin ORCID: 0000-0002-9014-9671, Wagner, Daniel, Koester, Philip, Tittgemeyer, Marc, Mercer-Chalmers-Bender, Katja ORCID: 0000-0002-3843-9065, Hurlemann, Rene ORCID: 0000-0003-2628-565X, Zhang, Jie, Gouzoulis-Mayfrank, Euphrosyne, Kendrick, Keith M. and Daumann, Joerg (2015). Smaller amygdala and medial prefrontal cortex predict escalating stimulant use. Brain, 138. S. 2074 - 2087. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2156

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Abstract

Drug addiction is a chronic, relapsing brain disorder. The identification of biomarkers that render individuals vulnerable for the transition from occasional drug use to addiction is of key importance to develop early intervention strategies. The aim of the present study was to prospectively assess brain structural markers for escalating drug use in two independent samples of occasional amphetamine-type stimulant users. At baseline occasional users of amphetamine and 3,4-methylenedioxymethamphetamine (cumulative lifetime use <= 10 units) underwent structural brain imaging and were followed up at 12 months and 24 months (Study 1, n = 38; Study 2, n = 28). Structural vulnerability markers for escalating amphetamine-type drug use were examined by comparing baseline grey matter volumes of participants who increased use with those who maintained or reduced use during the follow-up period. Participants in both samples who subsequently increased amphetamine-type drugs use displayed smaller medial prefrontal cortex volumes and, additionally, in the basolateral amygdala (Study 1) and dorsal striatum (Study 2). In both samples the baseline volumes were significantly negatively correlated with stimulant use during the subsequent 12 and 24 months. Additional multiple regression analyses on the pooled data sets revealed some evidence of a compound-specific association between the baseline volume of the left basolateral amygdala and the subsequent use of amphetamine. These findings indicate that smaller brain volumes in fronto-striato-limbic regions implicated in impulsivity and decision-making might render an individual vulnerable for the transition from occasional to escalating amphetamine-type stimulant use.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Becker, Benjamin UNSPECIFIED orcid.org/0000-0002-9014-9671 UNSPECIFIED Wagner, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Koester, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Mercer-Chalmers-Bender, Katja UNSPECIFIED orcid.org/0000-0002-3843-9065 UNSPECIFIED Hurlemann, Rene UNSPECIFIED orcid.org/0000-0003-2628-565X UNSPECIFIED Zhang, Jie UNSPECIFIED UNSPECIFIED UNSPECIFIED Gouzoulis-Mayfrank, Euphrosyne UNSPECIFIED UNSPECIFIED UNSPECIFIED Kendrick, Keith M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Daumann, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-399421
DOI:	10.1093/brain/awv113
Journal or Publication Title:	Brain
Volume:	138
Page Range:	S. 2074 - 2087
Date:	2015
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2156
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPULSIVE DRUG-SEEKING; DECISION-MAKING; ORBITOFRONTAL CORTEX; BASOLATERAL AMYGDALA; PERSONALITY-TRAITS; IMPULSE CONTROL; YOUNG-ADULTS; NEURAL BASIS; GRAY-MATTER; RISK-TAKING Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39942