Becker, Benjamin ORCID: 0000-0002-9014-9671, Wagner, Daniel, Koester, Philip, Tittgemeyer, Marc, Mercer-Chalmers-Bender, Katja ORCID: 0000-0002-3843-9065, Hurlemann, Rene ORCID: 0000-0003-2628-565X, Zhang, Jie, Gouzoulis-Mayfrank, Euphrosyne, Kendrick, Keith M. and Daumann, Joerg (2015). Smaller amygdala and medial prefrontal cortex predict escalating stimulant use. Brain, 138. S. 2074 - 2087. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2156

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Abstract

Drug addiction is a chronic, relapsing brain disorder. The identification of biomarkers that render individuals vulnerable for the transition from occasional drug use to addiction is of key importance to develop early intervention strategies. The aim of the present study was to prospectively assess brain structural markers for escalating drug use in two independent samples of occasional amphetamine-type stimulant users. At baseline occasional users of amphetamine and 3,4-methylenedioxymethamphetamine (cumulative lifetime use <= 10 units) underwent structural brain imaging and were followed up at 12 months and 24 months (Study 1, n = 38; Study 2, n = 28). Structural vulnerability markers for escalating amphetamine-type drug use were examined by comparing baseline grey matter volumes of participants who increased use with those who maintained or reduced use during the follow-up period. Participants in both samples who subsequently increased amphetamine-type drugs use displayed smaller medial prefrontal cortex volumes and, additionally, in the basolateral amygdala (Study 1) and dorsal striatum (Study 2). In both samples the baseline volumes were significantly negatively correlated with stimulant use during the subsequent 12 and 24 months. Additional multiple regression analyses on the pooled data sets revealed some evidence of a compound-specific association between the baseline volume of the left basolateral amygdala and the subsequent use of amphetamine. These findings indicate that smaller brain volumes in fronto-striato-limbic regions implicated in impulsivity and decision-making might render an individual vulnerable for the transition from occasional to escalating amphetamine-type stimulant use.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Becker, BenjaminUNSPECIFIEDorcid.org/0000-0002-9014-9671UNSPECIFIED
Wagner, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koester, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tittgemeyer, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mercer-Chalmers-Bender, KatjaUNSPECIFIEDorcid.org/0000-0002-3843-9065UNSPECIFIED
Hurlemann, ReneUNSPECIFIEDorcid.org/0000-0003-2628-565XUNSPECIFIED
Zhang, JieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gouzoulis-Mayfrank, EuphrosyneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kendrick, Keith M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daumann, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-399421
DOI: 10.1093/brain/awv113
Journal or Publication Title: Brain
Volume: 138
Page Range: S. 2074 - 2087
Date: 2015
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2156
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COMPULSIVE DRUG-SEEKING; DECISION-MAKING; ORBITOFRONTAL CORTEX; BASOLATERAL AMYGDALA; PERSONALITY-TRAITS; IMPULSE CONTROL; YOUNG-ADULTS; NEURAL BASIS; GRAY-MATTER; RISK-TAKINGMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39942

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