Universität zu Köln

Engel, L. A., Wittig, S., Bock, F., Sauerbier, L., Scheid, C., Holtick, U., Chemnitz, J-M, Hallek, M., Cursiefen, C. and Steven, P. (2015). Meibography and meibomian gland measurements in ocular graft-versus-host disease. Bone Marrow Transplant., 50 (7). S. 961 - 968. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

Meibomian gland loss in ocular GvHD was described as a mechanism contributing to dry eye and severe damage to the ocular surface. Infrared images of upper eyelid meibomian glands from 86 ocular GvHD patients, from 10 patients after allogeneic stem cell transplantation (aSCT) without ocular GvHD, from 32 patients prior to aSCT and from 30 healthy controls were analyzed retrospectively and evaluated using two grading schemes. The upper meibomian gland area (uMGA) was calculated and set in relation to the total tarsal area of the lid. Results demonstrate that meibomian gland loss is significantly increased in patients with ocular GvHD as well as in patients prior to aSCT in comparison with controls (P between 0.05 and < 0.001). Patients after aSCT without ocular GvHD had no significant difference in uMGA in comparison with controls. This study suggests that meibomian gland loss in GvHD patients is likely to be a multifactorial process that also occurs prior to aSCT, possibly due to underlying diseases and/or secondary to chemotherapy or irradiation. In addition, the question has to be addressed whether meibomian gland loss could serve as a predictor for the development of ocular GvHD. Overall, infrared meibography should be included in routine examination of patients undergoing aSCT and during follow-up.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Engel, L. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittig, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bock, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauerbier, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtick, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chemnitz, J-M UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-399711
DOI:	10.1038/bmt.2015.72
Journal or Publication Title:	Bone Marrow Transplant.
Volume:	50
Number:	7
Page Range:	S. 961 - 968
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DRY EYE; DIAGNOSIS Multiple languages Biophysics; Oncology; Hematology; Immunology; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39971