Weiss, Peter H. ORCID: 0000-0002-5230-9080, Herzog, Jan, Poetter-Nerger, Monika, Falk, Daniela, Herzog, Hans, Deuschl, Guenther, Volkmann, Jens ORCID: 0000-0002-9570-593X and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2015). Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers. Mov. Disord., 30 (8). S. 1121 - 1126. HOBOKEN: WILEY-BLACKWELL. ISSN 1531-8257

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Abstract

BackgroundSubthalamic deep brain stimulation (STN-DBS) can ameliorate gait disturbances in Parkinson's disease (PD). Using motor imagery and positron emission tomography (PET), we investigated how STN-DBS interacts with supraspinal locomotor centers in PD. MethodsTen PD patients with bilateral STN-DBS actually walked or stood still under STN-DBS ON or OFF conditions. Directly thereafter, subjects imagined walking or standing while changes in regional cerebral blood flow were measured by PET. ResultsIndependent of STN-DBS, imagined walking distance correlated with imagery duration. Compared with STN-DBS OFF, STN-DBS ON improved actual gait and increased imagined walking distance. Imagery of gait (vs. stance) induced activity in the supplementary motor area and the right superior parietal lobule for both STN-DBS conditions. The improvement of imagined gait during STN-DBS ON led to activity changes in the pedunculopontine nucleus/mesencephalic locomotor region (PPN/MLR). ConclusionsData suggest that STN-DBS improves Parkinsonian gait by modulating PPN/MLR activity. (c) 2015 International Parkinson and Movement Disorder Society

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Weiss, Peter H.UNSPECIFIEDorcid.org/0000-0002-5230-9080UNSPECIFIED
Herzog, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poetter-Nerger, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falk, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herzog, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, GuentherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volkmann, JensUNSPECIFIEDorcid.org/0000-0002-9570-593XUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
URN: urn:nbn:de:hbz:38-400511
DOI: 10.1002/mds.26229
Journal or Publication Title: Mov. Disord.
Volume: 30
Number: 8
Page Range: S. 1121 - 1126
Date: 2015
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1531-8257
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MOTOR IMAGERY; URINARY-BLADDER; DISEASE; DISTURBANCES; IMPAIRMENT; ACTIVATION; NETWORK; PETMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40051

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