Nuesken, Eva, Imschinetzki, Darja, Nuesken, Kai-Dietrich, Koerber, Friederike, Mentzel, Hans-Joachim, Peitz, Joachim, Bald, Martin, Buescher, Rainer, John, Ulrike, Klaus, Guenter, Konrad, Martin, Pape, Lars ORCID: 0000-0002-3635-6418, Toenshoff, Burkhard, Martin, David ORCID: 0000-0002-4279-3032, Weber, Lutz and Doetsch, Joerg (2015). Automated Greulich-Pyle bone age determination in children with chronic kidney disease. Pediatr. Nephrol., 30 (7). S. 1173 - 1180. NEW YORK: SPRINGER. ISSN 1432-198X

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Abstract

Growth restriction and retarded bone age are common findings in children with chronic kidney disease (CKD). We compared the automated BoneXpert (TM) method with the manual assessment of an X-ray of the non-dominant hand. In this retrospective multicenter study, 359 patients with CKD stages 2-5, aged 2-14.5 (girls) or 2.5-17 years (boys) were included. Bone age was determined manually by three experts (according to Greulich and Pyle). Automated determination of bone age was performed using the image analysis software BoneXpert (TM). There was a strong correlation between the automatic and the manual method (r = 0.983, p < 0.001). The automatic method tended to generate higher bone age values (0.64 +/- 0.73 years) in the younger patients (4-5 years) and to underestimate retardation or acceleration of bone age. The so-called bone health index (BHI) was reduced in comparison to the reference population. Bone health index standard deviation score (BHI-SDS) was not related to the stage of CKD, but weakly negatively correlated with plasma PTH concentrations (r = 0.12, p = 0.019). BoneXpert (TM) allows an objective, time-saving, and in general valid bone age assessment in children with CKD. Possible underestimation of retarded or accelerated bone age should be taken into account. Validation of the BHI needs further study.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Nuesken, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Imschinetzki, DarjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuesken, Kai-DietrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koerber, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mentzel, Hans-JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peitz, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bald, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buescher, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klaus, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konrad, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pape, LarsUNSPECIFIEDorcid.org/0000-0002-3635-6418UNSPECIFIED
Toenshoff, BurkhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, DavidUNSPECIFIEDorcid.org/0000-0002-4279-3032UNSPECIFIED
Weber, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doetsch, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-400719
DOI: 10.1007/s00467-015-3042-5
Journal or Publication Title: Pediatr. Nephrol.
Volume: 30
Number: 7
Page Range: S. 1173 - 1180
Date: 2015
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-198X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VALIDATION; WHITEHOUSE; TANNER; GROWTHMultiple languages
Pediatrics; Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40071

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