Universität zu Köln

Saraiva, Luis R. ORCID: 0000-0003-4079-0396, Ahuja, Gaurav, Ivandic, Ivan, Syed, Adnan S., Marioni, John C., Korsching, Sigrun I. ORCID: 0000-0002-5450-172X and Logan, Darren W. (2015). Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Sci Rep, 5. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Studies of the two major olfactory organs of rodents, the olfactory mucosa (OM) and the vomeronasal organ (VNO), unraveled the molecular basis of smell in vertebrates. However, some vertebrates lack a VNO. Here we generated and analyzed the olfactory transcriptome of the zebrafish and compared it to the olfactory transcriptomes of mouse to investigate the evolutionary and molecular relationship between single and dual olfactory systems. Our analyses revealed a high degree of molecular conservation, with orthologs of mouse olfactory cell-specific markers and all but one of their chemosensory receptor classes expressed in the single zebrafish olfactory organ. Zebrafish chemosensory receptor genes are expressed across a large dynamic range and their RNA abundance correlates positively with the number of neurons expressing that RNA. Thus we estimate the relative proportions of neuronal sub-types expressing different chemosensory receptors. Receptor repertoire size drives the absolute abundance of different classes of neurons, but we find similar underlying patterns in both species. Finally, we identified novel marker genes that characterize rare neuronal populations in both mouse and zebrafish. In sum, we find that the molecular and cellular mechanisms underpinning olfaction in teleosts and mammals are similar despite 430 million years of evolutionary divergence.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Saraiva, Luis R. UNSPECIFIED orcid.org/0000-0003-4079-0396 UNSPECIFIED Ahuja, Gaurav UNSPECIFIED UNSPECIFIED UNSPECIFIED Ivandic, Ivan UNSPECIFIED UNSPECIFIED UNSPECIFIED Syed, Adnan S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marioni, John C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Korsching, Sigrun I. UNSPECIFIED orcid.org/0000-0002-5450-172X UNSPECIFIED Logan, Darren W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-400858
DOI:	10.1038/srep11487
Journal or Publication Title:	Sci Rep
Volume:	5
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRPC2-EXPRESSING SENSORY NEURONS; RECEPTOR GENE REPERTOIRES; FORMYL PEPTIDE RECEPTORS; GUANYLYL CYCLASE-D; EXPRESSION LEVELS; NITRIC-OXIDE; EVOLUTIONARY DYNAMICS; ODORANT RECEPTORS; DANIO-RERIO; UROGUANYLIN Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/40085