Universität zu Köln

Weinmayr, Gudrun, Hennig, Frauke ORCID: 0000-0002-8769-7976, Fuks, Kateryna, Nonnemacher, Michael, Jakobs, Hermann, Moehlenkamp, Stefan, Erbel, Raimund, Joeckel, Karl-Heinz, Hoffmann, Barbara and Moebus, Susanne (2015). Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution. Environ. Health, 14. LONDON: BIOMED CENTRAL LTD. ISSN 1476-069X

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Abstract

Background: Studies investigating the link between long-term exposure to air pollution and incidence of diabetes are still scarce and results are inconsistent, possibly due to different compositions of the particle mixture. We investigate the long-term effect of traffic-specific and total particulate matter (PM) and road proximity on cumulative incidence of diabetes mellitus (mainly type 2) in a large German cohort. Methods: We followed prospectively 3607 individuals without diabetes at baseline (2000-2003) from the Heinz Nixdorf Recall Study in Germany (mean follow-up time 5.1 years). Mean annual exposures to total as well as traffic-specific PM10 and PM2.5 at residence were estimated using a chemistry transport model (EURAD, 1 km(2) resolution). Effect estimates for an increase of 1 mu g/m(3) in PM were obtained with Poisson regression adjusting for sex, age, body mass index, lifestyle factors, area-level and individual-level socio-economic status, and city. Results: 331 incident cases developed. Adjusted RRs for total PM10 and PM2.5 were 1.05 (95 %-CI: 1.00; 1.10) and 1.03 (95 %-CI: 0.95; 1.12), respectively. Markedly higher point estimates were found for local traffic-specific PM with RRs of 1.36 (95 %-CI: 0.98; 1.89) for PM10 and 1.36 (95 %-CI: 0.97; 1.89) for PM2.5. Individuals living closer than 100 m to a busy road had a more than 30 % higher risk (1.37; 95 %-CI: 1.04; 1.81) than those living further than 200 m away. Conclusions: Long-term exposure to total PM increases type two diabetes risk in the general population, as does living close to a major road. Local traffic-specific PM was related to higher risks for type two diabetes than total PM.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weinmayr, Gudrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennig, Frauke UNSPECIFIED orcid.org/0000-0002-8769-7976 UNSPECIFIED Fuks, Kateryna UNSPECIFIED UNSPECIFIED UNSPECIFIED Nonnemacher, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakobs, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Moehlenkamp, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Erbel, Raimund UNSPECIFIED UNSPECIFIED UNSPECIFIED Joeckel, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Moebus, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-401029
DOI:	10.1186/s12940-015-0031-x
Journal or Publication Title:	Environ. Health
Volume:	14
Date:	2015
Publisher:	BIOMED CENTRAL LTD
Place of Publication:	LONDON
ISSN:	1476-069X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; RISK-FACTORS; HEALTH; INFLAMMATION; ASSOCIATION; PREVALENCE; PARTICLES; MORTALITY; CHILDREN Multiple languages Environmental Sciences; Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40102