Universität zu Köln

Demir, M., Nigemeier, J., Kuetting, F., Bowe, A., Schramm, C., Hoffmann, V., Waldschmidt, D., Goeser, T. and Steffen, H-M. (2015). Clinical management of chronic hepatitis B infection: results from a registry at a German tertiary referral center. Infection, 43 (2). S. 153 - 163. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

We studied a cohort of adult patients with chronic hepatitis B (CHB) infection, followed at a tertiary referral liver center in Germany over 12.5 years to analyze the clinical features and impact of management on disease progression and survival of CHB patients in general and of those with CHB and HCC in particular. We retrospectively evaluated the medical records of 242 adult (age a parts per thousand yen 18 years) patients. CHB was defined as positive hepatitis B surface antigen (HBsAg) and/or HBV-DNA levels > 10 IU/mL for at least 6 months. Patient demographics, HBV markers, antiviral treatment, laboratory parameters, liver imaging and histology were recorded for each visit. HCC patients were divided into two groups and separately analyzed (group 1: n = 24, HCC at first visit and group 2: n = 11, HCC during surveillance). The mean age was 44 years in CHB patients without HCC (63 % male) and about 59 years in patients with HCC (77 % male). Antiviral therapy was given to 59 % of patients without HCC compared to only 25 % in group 1 and 18 % in group 2 with comparable median HBV DNA levels of approximately 36,000 IU/mL. There was no statistically significant difference concerning the HCC stages (Milan, UCSF, BCLC) at first diagnosis. Five-year survival was 19 % in group 1 vs. 64 % in group 2 (p = 0.019), with LTx performed in 12 vs. 45 %, respectively. Surveillance of CHB patients did not result in early stage detection of HCC but in a higher likelihood to receive potentially curative treatments.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Demir, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nigemeier, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuetting, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bowe, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schramm, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Waldschmidt, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeser, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steffen, H-M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-403383
DOI:	10.1007/s15010-015-0751-4
Journal or Publication Title:	Infection
Volume:	43
Number:	2
Page Range:	S. 153 - 163
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-0973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPATOCELLULAR-CARCINOMA; LIVER-TRANSPLANTATION; CIRRHOTIC-PATIENTS; VIRUS; DIAGNOSIS; THERAPY; RISK; RECOMMENDATIONS; EPIDEMIOLOGY; PREVENTION Multiple languages Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40338