Universität zu Köln

Schmidt, Daniel, Kollan, Christian, Stoll, Matthias, Stellbrink, Hans-Juergen, Plettenberg, Andreas, Faetkenheuer, Gerd, Bergmann, Frank, Bogner, Johannes R., Van Lunzen, Jan, Rockstroh, Juergen, Esser, Stefan, Jensen, Bjoern-Erik Ole, Horst, Heinz-August, Fritzsche, Carlos, Kuehne, Andrea, an der Heiden, Matthias ORCID: 0000-0001-5863-4549, Hamouda, Osamah and Bartmeyer, Barbara (2015). From pills to patients: an evaluation of data sources to determine the number of people living with HIV who are receiving antiretroviral therapy in Germany. BMC Public Health, 15. LONDON: BMC. ISSN 1471-2458

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Abstract

Background: This study aimed to determine the number of people living with HIV receiving antiretroviral therapy (ART) between 2006 and 2013 in Germany by using the available numbers of antiretroviral drug prescriptions and treatment data from the ClinSurv HIV cohort (CSH). Methods: The CSH is a multi-centre, open, long-term observational cohort study with an average number of 10.400 patients in the study period 2006-2013. ART has been documented on average for 86% of those CSH patients and medication history is well documented in the CSH. The antiretroviral prescription data (APD) are reported by billing centres for pharmacies covering >99% of nationwide pharmacy sales of all individuals with statutory health insurance (SHI) in Germany (similar to 85%). Exactly one thiacytidine-containing medication (TCM) with either emtricitabine or lamivudine is present in all antiretroviral fixed-dose combinations (FDCs). Thus, each daily dose of TCM documented in the APD is presumed to be representative of one person per day receiving ART. The proportion of non-TCM regimen days in the CSH was used to determine the corresponding number of individuals in the APD. Results: The proportion of CSH patients receiving TCMs increased continuously over time (from 85% to 93%; 2006-2013). In contrast, treatment interruptions declined remarkably (from 11% to 2%; 2006-2013). The total number of HIV-infected people with ART experience in Germany increased from 31,500 (95% CI 31,000-32,000) individuals to 54,000 (95% CI 53,000-55,500) over the observation period (including 16.3% without SHI and persons who had interrupted ART). An average increase of approximately 2,900 persons receiving ART was observed annually in Germany. Conclusions: A substantial increase in the number of people receiving ART was observed from 2006 to 2013 in Germany. Currently, the majority (93%) of antiretroviral regimens in the CSH included TCMs with ongoing use of FDCs. Based on these results, the future number of people receiving ART could be estimated by exclusively using TCM prescriptions, assuming that treatment guidelines will not change with respect to TCM use in ART regimens.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Kollan, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoll, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Stellbrink, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Plettenberg, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergmann, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogner, Johannes R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Lunzen, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Rockstroh, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Esser, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jensen, Bjoern-Erik Ole UNSPECIFIED UNSPECIFIED UNSPECIFIED Horst, Heinz-August UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritzsche, Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuehne, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED an der Heiden, Matthias UNSPECIFIED orcid.org/0000-0001-5863-4549 UNSPECIFIED Hamouda, Osamah UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartmeyer, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-404872
DOI:	10.1186/s12889-015-1598-4
Journal or Publication Title:	BMC Public Health
Volume:	15
Date:	2015
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-2458
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Mathematics and Computer Science > Institute of Computer Science
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GUIDELINES; AIDS; DEATH; MONOTHERAPY; NUCLEOSIDE; INHIBITORS; MORTALITY; REGIMEN; COHORT; ERA Multiple languages Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/40487