Universität zu Köln

Rhiem, K. and Schmutzler, R. K. (2015). Risk factors and prevention of breast cancer. Onkologe, 21 (3). S. 202 - 211. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

In addition to risk factors for breast cancer, such as hormonal influence, reproductive behavior and lifestyle factors, modern molecular analysis techniques lead to a rapidly increasing number of genetic risk factors for breast cancer. These factors attract heightened awareness of patients and doctors. Intensified surveillance strategies for early detection and prophylactic risk-reducing surgery exist for members of well-defined high-risk groups (e.g. BRCA1 and BRCA2 mutation carriers). New genes that will be discovered in the near future will only be moderate and low risk genes. Preventive strategies that have been proven to be efficient for members of the high-risk group are certainly not appropriate to be easily transferred to members of moderate or low-risk groups. It has now become obvious that specific genotypes are associated with specific tumor phenotypes. Breast cancers of BRCA1 mutation carriers are mostly triple negative, while BRCA2 and RAD51C mutation carriers show luminal B and luminal A breast cancers, respectively. These tumor phenotypes are associated with a specific course of disease and corresponding response rates to targeted therapies. Epidemiological and clinical studies have to be carried out to deliver these data for the newly identified risk genes and can then form the basis for patients and doctors within the decision-making process for or against undertaking risk-adapted preventive measures.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rhiem, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, R. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-406187
DOI:	10.1007/s00761-014-2837-5
Journal or Publication Title:	Onkologe
Volume:	21
Number:	3
Page Range:	S. 202 - 211
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRCA2 MUTATION CARRIERS; OVARIAN-CANCER; HODGKINS-DISEASE; WOMEN; CHILDHOOD; RECEPTOR; MASTECTOMY; THERAPY; RAD51C; GENES Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40618