Universität zu Köln

Wagner, Daniel, Koester, Philip, Becker, Benjamin ORCID: 0000-0002-9014-9671, Gouzoulis-Mayfrank, Euphrosyne, Hellmich, Martin and Daumann, Joerg (2015). A longitudinal study of self-reported psychopathology in early ecstasy and amphetamine users. Psychopharmacology, 232 (5). S. 897 - 906. NEW YORK: SPRINGER. ISSN 1432-2072

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Abstract

It still remains unclear whether psychopathological abnormalities described in human 3,4-methylenedioxymethamphetamine users (MDMA users) and d-amphetamine users (AMPH users) existed before the beginning of regular use or if they develop with ongoing use. The present study was conducted in order to assess this relationship and to overcome previous methodological shortcomings. A longitudinal cohort study in 96 beginning MDMA and d-amphetamine users between 2006 and 2011 with a follow-up duration of 24 months. In order to explore the impact of MDMA and AMPH use on self-reported psychopathology (measured by the Symptom Checklist-90-Revised), mixed models for repeated measures were fitted. In order to examine the impact of previous psychopathology on subsequent use, partial correlation analyses and linear regression analyses were applied. Over the course of the 2-year follow-up period, 31 subjects used neither MDMA nor AMPH (non-users); 65 subjects used both MDMA and AMPH: 37 subjects used between 1 and 14 tablets of MDMA and 28 subjects used 15 or more tablets of MDMA. Thirty-three subjects used between 1 and 14 g of AMPH, and 32 subjects used 15 g or more. No associations concerning MDMA/AMPH use and development of self-reported psychopathology were found. However, there was a significant relationship between globally increased self-reported psychopathology-particularly psychoticism-at the beginning of the study and subsequent AMPH use. The data of the present study suggest that a certain psychopathological profile could form a risk factor for later use of amphetamines.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wagner, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Koester, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Benjamin UNSPECIFIED orcid.org/0000-0002-9014-9671 UNSPECIFIED Gouzoulis-Mayfrank, Euphrosyne UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Daumann, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-406562
DOI:	10.1007/s00213-014-3722-z
Journal or Publication Title:	Psychopharmacology
Volume:	232
Number:	5
Page Range:	S. 897 - 906
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-2072
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SEROTONIN TRANSPORTER AVAILABILITY; MDMA USERS; YOUNG-ADULTS; METHAMPHETAMINE USE; RECREATIONAL ECSTASY/MDMA; CANNABIS USE; QUITTING ECSTASY; HIGH PREVALENCE; POLYDRUG USERS; DRUG-USERS Multiple languages Neurosciences; Pharmacology & Pharmacy; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40656