Amft, Maren, Bzdok, Danilo, Laird, Angela R., Fox, Peter T., Schilbach, Leonhard ORCID: 0000-0001-5547-8309 and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2015). Definition and characterization of an extended social-affective default network. Brain Struct. Funct., 220 (2). S. 1031 - 1050. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-2661

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Abstract

Recent evidence suggests considerable overlap between the default mode network (DMN) and regions involved in social, affective and introspective processes. We considered these overlapping regions as the social-affective part of the DMN. In this study, we established a robust mapping of the underlying brain network formed by these regions and those strongly connected to them (the extended social-affective default network). We first seeded meta-analytic connectivity modeling and resting-state analyses in the meta-analytically defined DMN regions that showed statistical overlap with regions associated with social and affective processing. Consensus connectivity of each seed was subsequently delineated by a conjunction across both connectivity analyses. We then functionally characterized the ensuing regions and performed several cluster analyses. Among the identified regions, the amygdala/hippocampus formed a cluster associated with emotional processes and memory functions. The ventral striatum, anterior cingulum, subgenual cingulum and ventromedial prefrontal cortex formed a heterogeneous subgroup associated with motivation, reward and cognitive modulation of affect. Posterior cingulum/precuneus and dorsomedial prefrontal cortex were associated with mentalizing, self-reference and autobiographic information. The cluster formed by the temporo-parietal junction and anterior middle temporal sulcus/gyrus was associated with language and social cognition. Taken together, the current work highlights a robustly interconnected network that may be central to introspective, socio-affective, that is, self- and other-related mental processes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Amft, MarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bzdok, DaniloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laird, Angela R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fox, Peter T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schilbach, LeonhardUNSPECIFIEDorcid.org/0000-0001-5547-8309UNSPECIFIED
Eickhoff, Simon B.UNSPECIFIEDorcid.org/0000-0001-6363-2759UNSPECIFIED
URN: urn:nbn:de:hbz:38-406702
DOI: 10.1007/s00429-013-0698-0
Journal or Publication Title: Brain Struct. Funct.
Volume: 220
Number: 2
Page Range: S. 1031 - 1050
Date: 2015
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1863-2661
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TEMPORO-PARIETAL JUNCTION; MEDIAL PREFRONTAL CORTEX; LIKELIHOOD ESTIMATION METAANALYSIS; RIGHT TEMPOROPARIETAL JUNCTION; STATE FUNCTIONAL CONNECTIVITY; ANTERIOR CINGULATE CORTEX; MODE NETWORK; BRAIN-FUNCTION; ALZHEIMERS-DISEASE; SELF-REFLECTIONMultiple languages
Anatomy & Morphology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40670

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