Universität zu Köln

Maier, Franziska, Ellereit, Anna L., Eggers, Carsten, Lewis, Catharine J., Pelzer, Esther A., Kalbe, Elke, Ernstmann, Nicole ORCID: 0000-0001-7685-6110, Prigatano, George P., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Timmermann, Lars (2015). Development and psychometric evaluation of a scale to measure impaired self-awareness of hyper- and hypokinetic movements in Parkinson's disease. J. Int. Neuropsychol. Soc., 21 (3). S. 221 - 231. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1469-7661

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Abstract

Objective: Patients with Parkinson's disease (PD) can show impaired self-awareness of motor deficits (ISAm). We developed a new scale that measures ISAm severity of hyper- and hypokinetic movements in PD during medication on state and defined its psychometric criteria. Method: Included were 104 right-handed, non-depressed, non-demented patients. Concerning ISAm, 38 motor symptoms were assessed using seven tasks, which were performed and self-rated concerning presence of deficit (yes/no) by all patients. The whole procedure was videotaped. Motor symptoms were then evaluated by two independent experts, blinded for patient's ratings, concerning presence, awareness of deficit, and severity. Exploratory principal component analysis (promax rotation) was applied to reduce items. Principal axis factoring was conducted to extract factors. Reliability was examined regarding internal consistency, split-half reliability, and interrater reliability. Validity was verified by applying two additional measures of ISAm. Results: Of the initial 38 symptoms, 15 remained, assessed in five motor tasks and merged to a total severity score. Factor analysis resulted in a four factor solution (dyskinesia, resting tremor right hand, resting tremor left hand, bradykinesia). For all subscales and the total score, measures of reliability (values 0.64-0.89) and validity (effect sizes > 0.3) were satisfactory. Descriptive results showed that 66% of patients had signs of ISAm (median 2, range 0-15), with ISAm being most distinct for dyskinesia. Conclusions: We provide the first validation of a test for ISAm in PD. Using this instrument, future studies can further analyze the pathophysiology of ISAm, the psychosocial sequelae, therapeutic strategies and compliance with therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maier, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Ellereit, Anna L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Catharine J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pelzer, Esther A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernstmann, Nicole UNSPECIFIED orcid.org/0000-0001-7685-6110 UNSPECIFIED Prigatano, George P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-406968
DOI:	10.1017/S1355617715000107
Journal or Publication Title:	J. Int. Neuropsychol. Soc.
Volume:	21
Number:	3
Page Range:	S. 221 - 231
Date:	2015
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1469-7661
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANOSOGNOSIA; DYSKINESIAS; UNAWARENESS; DEFICITS; NEGLECT; LESIONS Multiple languages Clinical Neurology; Neurosciences; Psychiatry; Psychology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40696