Seidel, Maria, King, Joseph A., Ritschel, Franziska, Doepmann, Johanna, Buehren, Katharina, Seitz, Jochen ORCID: 0000-0002-0110-7980, Roessner, Veit, Westphal, Sabine, Egberts, Karin, Burghardt, Roland, Wewetzer, Christoph, Fleischhaker, Christian, Hebebrand, Johannes, Herpertz-Dahlmann, Beate and Ehrlich, Stefan ORCID: 0000-0003-2132-4445 (2015). Serum visfatin concentration in acutely ill and weight-recovered patients with anorexia nervosa. Psychoneuroendocrinology, 53. S. 127 - 136. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 0306-4530

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Abstract

Visfatin is a recently described protein that is thought to regulate the process of adipocyte differentiation. Findings suggest that visfatin may be actively involved in the control of weight regulatory networks. However, to what extent and which rote it plays in eating disorders is still poorly understood, as mixed results have been reported. The aim of the current study was to investigate serum visfatin concentrations on a cross sectional sample between acute anorexia nervosa patients (n =44), weight recovered patients (n = 13) and healthy controls (n = 46) and a longitudinal sample of acute patients (n = 57) during weight recovery at three different time-points. Results did not show significant differences in visfatin between the three groups; however, acute patients showed a higher visfatin/BMI-SDS ratio than controls and recovered patients. Longitudinal results revealed an increase of visfatin levels during therapy. Our results suggest that high ratios of visfatin/BMI-SDS could be a state marker in acute anorexia nervosa, displaying a compensatory mechanism of the individual to maintain normal visfatin levels under malnourished conditions. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Seidel, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
King, Joseph A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ritschel, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doepmann, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buehren, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seitz, JochenUNSPECIFIEDorcid.org/0000-0002-0110-7980UNSPECIFIED
Roessner, VeitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westphal, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Egberts, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burghardt, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wewetzer, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleischhaker, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hebebrand, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herpertz-Dahlmann, BeateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehrlich, StefanUNSPECIFIEDorcid.org/0000-0003-2132-4445UNSPECIFIED
URN: urn:nbn:de:hbz:38-407101
DOI: 10.1016/j.psyneuen.2014.12.010
Journal or Publication Title: Psychoneuroendocrinology
Volume: 53
Page Range: S. 127 - 136
Date: 2015
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication: OXFORD
ISSN: 0306-4530
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COLONY-ENHANCING FACTOR; BODY-MASS INDEX; TYPE-2 DIABETES-MELLITUS; MORBIDLY OBESE WOMEN; POLYCYSTIC-OVARY-SYNDROME; MESSENGER-RNA EXPRESSION; PLASMA VISFATIN; VISCERAL FAT; ADIPOSE-TISSUE; WAIST CIRCUMFERENCEMultiple languages
Endocrinology & Metabolism; Neurosciences; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40710

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