Zeschel, Eike, Bingmann, Tiffany, Bechdolf, Andreas, Krueger-Oezguerdal, Seza, Correll, Christoph U., Leopold, Karolina, Pfennig, Andrea, Bauer, Michael and Juckel, Georg (2015). Temperament and prodromal symptoms prior to first manic/hypomanic episodes: Results from a pilot study. J. Affect. Disord., 173. S. 39 - 45. AMSTERDAM: ELSEVIER. ISSN 1573-2517

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Abstract

Background: Prodromal symptoms prior to first episode mania/hypomania have been reported. However, the relationship between temperament and manic/hypomanic prodromal symptoms has not been investigated. We hypothesized that subjects scoring higher on cyclothymic and irritable temperament scales show more manic/hypomanic prodromal symptoms. Method: Euthymic patients diagnosed with bipolar-I or -ll disorder within 8 years underwent retrospective assessments with the Temperament Evaluation of Memphis, Pisa, Paris and San Diegoautoquestionnaire (TEMPS-A) and the Bipolar Prod rome Symptom Scale-Retrospective (BPSS-R). Results: Among 39 subjects (36.1 +/- 9.9 years, females=59%, bipolar-I-62%) 100% and 92.3% reported subthreshold mania (mean-7.4 +/- 2.9) or subthreshold depressive symptoms (mean-2 +/- 1.5), and 87.2% and 43.6% reported general psychopathology (mean-3.2 +/- 2.0) or subthreshold psychotic symptoms (mean-0.7 +/- 1.0) prior to their first hypo-/manic episode. Subjects with higher cyclothymic and irritable temperament scores showed more subthreshold symptoms prior to the first manic/ hypomanic episode, mainly subthreshold hypo-/manic symptoms (cyclothymic temperament r=0.430; p=0.006; irritable temperament r=0.330; p =0.040), general psychopathology symptoms (cyclothymic temperament r=0.316; p=0.05; irritable temperament r=0.349; p=0.029) and subthreshold psychotic symptoms (cyclothymic temperament r=0.413; p=0.009). In regression analyses, cyclothymic temperament explained 16.1% and 12.5% of the variance of the BPSS-R total score (p=0.045) and psychosis subscore (p =0.029). Limitations: Retrospective study, no control group, small sample size. Conclusion: We present data, which indicate a relationship between cyclothymic and irritable temperament and proclromal symptoms prior to the first manic/hypomanic episode. These findings support the notion that assessing cyclothymic temperament to identify people at-risk of developing bipolar-I and -ll disorder may help to increase the predictive validity of applied at-risk criteria. (C) 2014 Elsevier B.V. All rights reserved

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zeschel, EikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bingmann, TiffanyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechdolf, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krueger-Oezguerdal, SezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Correll, Christoph U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leopold, KarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfennig, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juckel, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-407209
DOI: 10.1016/j.jad.2014.10.031
Journal or Publication Title: J. Affect. Disord.
Volume: 173
Page Range: S. 39 - 45
Date: 2015
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1573-2517
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HELP-SEEKING ADOLESCENTS; BIPOLAR DISORDER; TEMPS-A; NEUROCOGNITIVE FEATURES; EARLY INTERVENTION; RATING-SCALE; RISK; MOOD; SCHIZOPHRENIA; MANIAMultiple languages
Clinical Neurology; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40720

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