Universität zu Köln

Shatnyeva, Olga M., Hansen, Hinrich P., Reiners, Katrin S., Sauer, Maike, Vyas, Maulik ORCID: 0000-0003-2996-4682 and von Strandmann, Elke Pogge (2015). DNA damage response and evasion from immunosurveillance in CLL: new options for NK cell-based immunotherapies. Front. Genet., 6. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-8021

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Abstract

Chronic lyrnphocytic leukemia (CLL) is the most prominent B cell malignancy among adults in the Western world and characterized by a clonal expansion of B cells. The patients suffer from severe immune defects resulting in increased susceptibility to infections and failure to generate an antitumor immune response. Defects in both, DNA damage response (DDR) pathway and crosstalk with the tissue microenvironment have been reported to play a crucial role for the survival of CLL cells, therapy resistance and impaired immune response. To this end, major advances over the past years have highlighted several T cell immune evasion mechanisms in CLL. Here, we discuss the consequences of an impaired DDR pathway for detection and elimination of CLL cells by natural killer (NK) cells. NK cells are considered to be a major component of the irnmunosurveillance in leukemia but NK cell activity is impaired in CLL. Restoration of NK cell activity using immunoligands and immunoconstructs in combination with the conventional chemotherapy may provide a future perspective for CLL treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shatnyeva, Olga M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansen, Hinrich P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reiners, Katrin S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauer, Maike UNSPECIFIED UNSPECIFIED UNSPECIFIED Vyas, Maulik UNSPECIFIED orcid.org/0000-0003-2996-4682 UNSPECIFIED von Strandmann, Elke Pogge UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-407786
DOI:	10.3389/fgene.2015.00011
Journal or Publication Title:	Front. Genet.
Volume:	6
Date:	2015
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-8021
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC LYMPHOCYTIC-LEUKEMIA; IDENTIFIES RECURRENT MUTATIONS; B-ASSOCIATED TRANSCRIPT-3; POTENT ANTITUMOR-ACTIVITY; SOLUBLE NKG2D LIGANDS; I-RELATED CHAIN; TUMOR-CELLS; GENOMIC ABERRATIONS; SUPPRESSOR-CELLS; SELF-TOLERANCE Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40778