Blanco, Ignacio ORCID: 0000-0002-7414-7481, Kuchenbaecker, Karoline, Cuadras, Daniel ORCID: 0000-0001-8780-1764, Wang, Xianshu, Barrowdale, Daniel ORCID: 0000-0003-1661-3939, Ruiz de Garibay, Gorka ORCID: 0000-0001-9936-8419, Librado, Pablo ORCID: 0000-0001-5974-2189, Sanchez-Gracia, Alejandro ORCID: 0000-0003-4543-4577, Rozas, Julio ORCID: 0000-0002-6839-9148, Bonifaci, Nuria, McGuffog, Lesley, Pankratz, Vernon S., Islam, Abul ORCID: 0000-0002-7274-0855, Mateo, Francesca ORCID: 0000-0002-2342-7010, Berenguer, Antoni, Petit, Anna, Catala, Isabel, Brunet, Joan ORCID: 0000-0003-1945-3512, Feliubadalo, Lidia ORCID: 0000-0002-1736-0112, Tornero, Eva, Benitez, Javier, Osorio, Ana ORCID: 0000-0001-8124-3984, Cajal, Teresa Ramon Y., Nevanlinna, Heli, Aittomaki, Kristiina, Arun, Banu K., Toland, Amanda E., Karlan, Beth Y., Walsh, Christine, Lester, Jenny, Greene, Mark H., Mai, Phuong L., Nussbaum, Robert L., Andrulis, Irene L., Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Barkardottir, Rosa B., Jakubowska, Anna ORCID: 0000-0002-5650-0501, Lubinski, Jan ORCID: 0000-0003-2931-3003, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Claes, Kathleen ORCID: 0000-0003-0841-7372, Van Maerken, Tom, Diez, Orland, Hansen, Thomas V., Jonson, Lars, Gerdes, Anne-Marie ORCID: 0000-0002-0328-3320, Ejlertsen, Bent, de la Hoya, Miguel ORCID: 0000-0002-8113-1410, Caldes, Trinidad, Dunning, Alison M., Oliver, Clare, Fineberg, Elena, Cook, Margaret, Peock, Susan, McCann, Emma, Murray, Alex, Jacobs, Chris ORCID: 0000-0002-9557-9080, Pichert, Gabriella, Lalloo, Fiona, Chu, Carol, Dorkins, Huw ORCID: 0000-0001-8421-9939, Paterson, Joan, Ong, Kai-Ren, Teixeira, Manuel R., Hogervorst, Frans B. L., van der Hout, Annemarie H., Seynaeve, Caroline, van der Luijt, Rob B., Ligtenberg, Marjolijn J. L., Devilee, Peter ORCID: 0000-0002-8023-2009, Wijnen, Juul T., Rookus, Matti A., Meijers-Heijboer, Hanne E. J., Blok, Marinus J., van den Ouweland, Ans M. W., Aalfs, Cora M., Rodriguez, Gustavo C., Phillips, Kelly-Anne A., Piedmonte, Marion, Nerenstone, Stacy R., Bae-Jump, Victoria L., O'Malley, David M., Ratner, Elena S., Schmutzler, Rita K., Wappenschmidt, Barbara, Rhiem, Kerstin, Engel, Christoph ORCID: 0000-0002-7247-282X, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert ORCID: 0000-0003-4523-8808, Plendl, Hansjoerg J., Niederacher, Dieter, Sutter, Christian, Wang-Gohrke, Shan, Steinemann, Doris, Preisler-Adams, Sabine, Kast, Karin, Varon-Mateeva, Raymonda, Gehrig, Andrea, Bojesen, Anders ORCID: 0000-0003-4289-8595, Pedersen, Inge Sokilde ORCID: 0000-0002-9902-8040, Sunde, Lone ORCID: 0000-0002-8479-165X, Jensen, Uffe Birk ORCID: 0000-0002-6205-6355, Thomassen, Mads, Kruse, Torben A., Foretova, Lenka, Peterlongo, Paolo ORCID: 0000-0001-6951-6855, Bernard, Loris, Peissel, Bernard ORCID: 0000-0001-9233-3571, Scuvera, Giulietta, Manoukian, Siranoush, Radice, Paolo ORCID: 0000-0001-6298-4111, Ottini, Laura, Montagna, Marco, Agata, Simona, Maugard, Christine, Simard, Jacques, Soucy, Penny, Berger, Andreas, Fink-Retter, Anneliese, Singer, Christian F., Rappaport, Christine, Geschwantler-Kaulich, Daphne, Tea, Muy-Kheng, Pfeiler, Georg, John, Esther M., Miron, Alex, Neuhausen, Susan L., Terry, Mary Beth, Chung, Wendy K., Daly, Mary B., Goldgar, David E., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elisabeth J., Fostira, Florentia, Konstantopoulou, Irene ORCID: 0000-0002-0470-0309, Garber, Judy, Godwin, Andrew K., Olah, Edith, Narod, Steven A., Rennert, Gad, Paluch, Shani Shimon, Laitman, Yael, Friedman, Eitan, Liljegren, Annelie, Rantala, Johanna, Stenmark-Askmalm, Marie, Loman, Niklas, Imyanitov, Evgeny N., Hamann, Ute, Spurdle, Amanda B., Healey, Sue, Weitzel, Jeffrey N., Herzog, Josef, Margileth, David, Gorrini, Chiara ORCID: 0000-0002-5239-6671, Esteller, Manel ORCID: 0000-0003-4490-6093, Gomez, Antonio, Sayols, Sergi ORCID: 0000-0002-3877-4170, Vidal, Enrique ORCID: 0000-0002-4217-1807, Heyn, Holger ORCID: 0000-0002-3276-1889, Stoppa-Lyonnet, Dominique, Leone, Melanie, Barjhoux, Laure, Fassy-Colcombet, Marion, de Pauw, Antoine, Lasset, Christine, Ferrer, Sandra Fert, Castera, Laurent ORCID: 0000-0002-0459-3400, Berthet, Pascaline, Cornelis, Francois, Bignon, Yves-Jean, Damiola, Francesca ORCID: 0000-0002-0238-1252, Mazoyer, Sylvie ORCID: 0000-0002-2135-0160, Sinilnikova, Olga M., Maxwell, Christopher A., Vijai, Joseph, Robson, Mark ORCID: 0000-0002-3109-1692, Kauff, Noah ORCID: 0000-0001-7242-6156, Corines, Marina J., Villano, Danylko, Cunningham, Julie, Lee, Adam, Lindor, Noralane, Lazaro, Conxi, Easton, Douglas F., Offit, Kenneth, Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587, Couch, Fergus J., Antoniou, Antonis C. and Angel Pujana, Miguel (2015). Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers. PLoS One, 10 (4). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Forty-one single nucleotide polymorphisms (SNPs) were genotyped in 15,252 BRCA1 and 8,211 BRCA2 mutation carriers and subsequently analyzed using a retrospective likelihood approach. The association of HMMR rs299290 with breast cancer risk in BRCA1 mutation carriers was confirmed: per-allele hazard ratio (HR) = 1.10, 95% confidence interval (CI) 1.04 - 1.15, p = 1.9 x 10(-4) (false discovery rate (FDR)-adjusted p = 0.043). Variation in CSTF1, located next to AURKA, was also found to be associated with breast cancer risk in BRCA2 mutation carriers: rs2426618 per-allele HR = 1.10, 95% CI 1.03 - 1.16, p = 0.005 (FDR-adjusted p = 0.045). Assessment of pairwise interactions provided suggestions (FDR-adjusted p(interaction) values > 0.05) for deviations from the multiplicative model for rs299290 and CSTF1 rs6064391, and rs299290 and TUBG1 rs11649877 in both BRCA1 and BRCA2 mutation carriers. Following these suggestions, the expression of HMMR and AURKA or TUBG1 in sporadic breast tumors was found to potentially interact, influencing patients' survival. Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Blanco, IgnacioUNSPECIFIEDorcid.org/0000-0002-7414-7481UNSPECIFIED
Kuchenbaecker, KarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuadras, DanielUNSPECIFIEDorcid.org/0000-0001-8780-1764UNSPECIFIED
Wang, XianshuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrowdale, DanielUNSPECIFIEDorcid.org/0000-0003-1661-3939UNSPECIFIED
Ruiz de Garibay, GorkaUNSPECIFIEDorcid.org/0000-0001-9936-8419UNSPECIFIED
Librado, PabloUNSPECIFIEDorcid.org/0000-0001-5974-2189UNSPECIFIED
Sanchez-Gracia, AlejandroUNSPECIFIEDorcid.org/0000-0003-4543-4577UNSPECIFIED
Rozas, JulioUNSPECIFIEDorcid.org/0000-0002-6839-9148UNSPECIFIED
Bonifaci, NuriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGuffog, LesleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pankratz, Vernon S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Islam, AbulUNSPECIFIEDorcid.org/0000-0002-7274-0855UNSPECIFIED
Mateo, FrancescaUNSPECIFIEDorcid.org/0000-0002-2342-7010UNSPECIFIED
Berenguer, AntoniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petit, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Catala, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunet, JoanUNSPECIFIEDorcid.org/0000-0003-1945-3512UNSPECIFIED
Feliubadalo, LidiaUNSPECIFIEDorcid.org/0000-0002-1736-0112UNSPECIFIED
Tornero, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benitez, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osorio, AnaUNSPECIFIEDorcid.org/0000-0001-8124-3984UNSPECIFIED
Cajal, Teresa Ramon Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nevanlinna, HeliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aittomaki, KristiinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arun, Banu K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toland, Amanda E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karlan, Beth Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walsh, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lester, JennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greene, Mark H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mai, Phuong L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nussbaum, Robert L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, Irene L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Domchek, Susan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nathanson, Katherine L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rebbeck, Timothy R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barkardottir, Rosa B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakubowska, AnnaUNSPECIFIEDorcid.org/0000-0002-5650-0501UNSPECIFIED
Lubinski, JanUNSPECIFIEDorcid.org/0000-0003-2931-3003UNSPECIFIED
Durda, KatarzynaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaworska-Bieniek, KatarzynaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Claes, KathleenUNSPECIFIEDorcid.org/0000-0003-0841-7372UNSPECIFIED
Van Maerken, TomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diez, OrlandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansen, Thomas V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jonson, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerdes, Anne-MarieUNSPECIFIEDorcid.org/0000-0002-0328-3320UNSPECIFIED
Ejlertsen, BentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de la Hoya, MiguelUNSPECIFIEDorcid.org/0000-0002-8113-1410UNSPECIFIED
Caldes, TrinidadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunning, Alison M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oliver, ClareUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fineberg, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cook, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peock, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McCann, EmmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murray, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobs, ChrisUNSPECIFIEDorcid.org/0000-0002-9557-9080UNSPECIFIED
Pichert, GabriellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lalloo, FionaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chu, CarolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dorkins, HuwUNSPECIFIEDorcid.org/0000-0001-8421-9939UNSPECIFIED
Paterson, JoanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ong, Kai-RenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teixeira, Manuel R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogervorst, Frans B. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Hout, Annemarie H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seynaeve, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Luijt, Rob B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ligtenberg, Marjolijn J. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devilee, PeterUNSPECIFIEDorcid.org/0000-0002-8023-2009UNSPECIFIED
Wijnen, Juul T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rookus, Matti A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meijers-Heijboer, Hanne E. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blok, Marinus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Ouweland, Ans M. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aalfs, Cora M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez, Gustavo C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phillips, Kelly-Anne A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piedmonte, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nerenstone, Stacy R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bae-Jump, Victoria L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Malley, David M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ratner, Elena S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wappenschmidt, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rhiem, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
Meindl, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ditsch, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arnold, NorbertUNSPECIFIEDorcid.org/0000-0003-4523-8808UNSPECIFIED
Plendl, Hansjoerg J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niederacher, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sutter, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang-Gohrke, ShanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinemann, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preisler-Adams, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kast, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Varon-Mateeva, RaymondaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gehrig, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bojesen, AndersUNSPECIFIEDorcid.org/0000-0003-4289-8595UNSPECIFIED
Pedersen, Inge SokildeUNSPECIFIEDorcid.org/0000-0002-9902-8040UNSPECIFIED
Sunde, LoneUNSPECIFIEDorcid.org/0000-0002-8479-165XUNSPECIFIED
Jensen, Uffe BirkUNSPECIFIEDorcid.org/0000-0002-6205-6355UNSPECIFIED
Thomassen, MadsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kruse, Torben A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foretova, LenkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peterlongo, PaoloUNSPECIFIEDorcid.org/0000-0001-6951-6855UNSPECIFIED
Bernard, LorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peissel, BernardUNSPECIFIEDorcid.org/0000-0001-9233-3571UNSPECIFIED
Scuvera, GiuliettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manoukian, SiranoushUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radice, PaoloUNSPECIFIEDorcid.org/0000-0001-6298-4111UNSPECIFIED
Ottini, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montagna, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agata, SimonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maugard, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simard, JacquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soucy, PennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berger, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink-Retter, AnnelieseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singer, Christian F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rappaport, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geschwantler-Kaulich, DaphneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tea, Muy-KhengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeiler, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, Esther M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miron, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhausen, Susan L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Terry, Mary BethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chung, Wendy K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daly, Mary B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldgar, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janavicius, RamunasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dorfling, Cecilia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Rensburg, Elisabeth J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fostira, FlorentiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konstantopoulou, IreneUNSPECIFIEDorcid.org/0000-0002-0470-0309UNSPECIFIED
Garber, JudyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Godwin, Andrew K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olah, EdithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Narod, Steven A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rennert, GadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paluch, Shani ShimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laitman, YaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedman, EitanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liljegren, AnnelieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rantala, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stenmark-Askmalm, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loman, NiklasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Imyanitov, Evgeny N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamann, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spurdle, Amanda B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Healey, SueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weitzel, Jeffrey N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herzog, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Margileth, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gorrini, ChiaraUNSPECIFIEDorcid.org/0000-0002-5239-6671UNSPECIFIED
Esteller, ManelUNSPECIFIEDorcid.org/0000-0003-4490-6093UNSPECIFIED
Gomez, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sayols, SergiUNSPECIFIEDorcid.org/0000-0002-3877-4170UNSPECIFIED
Vidal, EnriqueUNSPECIFIEDorcid.org/0000-0002-4217-1807UNSPECIFIED
Heyn, HolgerUNSPECIFIEDorcid.org/0000-0002-3276-1889UNSPECIFIED
Stoppa-Lyonnet, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leone, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barjhoux, LaureUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fassy-Colcombet, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Pauw, AntoineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lasset, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferrer, Sandra FertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castera, LaurentUNSPECIFIEDorcid.org/0000-0002-0459-3400UNSPECIFIED
Berthet, PascalineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornelis, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bignon, Yves-JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damiola, FrancescaUNSPECIFIEDorcid.org/0000-0002-0238-1252UNSPECIFIED
Mazoyer, SylvieUNSPECIFIEDorcid.org/0000-0002-2135-0160UNSPECIFIED
Sinilnikova, Olga M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maxwell, Christopher A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vijai, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robson, MarkUNSPECIFIEDorcid.org/0000-0002-3109-1692UNSPECIFIED
Kauff, NoahUNSPECIFIEDorcid.org/0000-0001-7242-6156UNSPECIFIED
Corines, Marina J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villano, DanylkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cunningham, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindor, NoralaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lazaro, ConxiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Offit, KennethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chenevix-Trench, GeorgiaUNSPECIFIEDorcid.org/0000-0002-1878-2587UNSPECIFIED
Couch, Fergus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antoniou, Antonis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angel Pujana, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-409353
DOI: 10.1371/journal.pone.0120020
Journal or Publication Title: PLoS One
Volume: 10
Number: 4
Date: 2015
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENE-EXPRESSION SIGNATURE; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; POLYMORPHISM; MODIFIERSMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40935

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