Universität zu Köln

Bleuel, Judith, Zaucke, Frank, Brueggemann, Gert-Peter and Niehoff, Anja ORCID: 0000-0002-4165-0929 (2015). Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review. PLoS One, 10 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Chondrocytes reorganize the extracellular matrix of articular cartilage in response to externally applied loads. Thereby, different loading characteristics lead to different biological responses. Despite of active research in this area, it is still unclear which parts of the extracellular matrix adapt in what ways, and how specific loading characteristics affect matrix changes. This review focuses on the influence of cyclic tensile strain on chondrocyte metabolism in vitro. It also aimed to identify anabolic or catabolic chondrocyte responses to different loading protocols. The key findings show that loading cells up to 3% strain, 0.17 Hz, and 2 h, resulted in weak or no biological responses. Loading between 3-10% strain, 0.17-0.5 Hz, and 2-12 h led to anabolic responses; and above 10% strain, 0.5 Hz, and 12 h catabolic events predominated. However, this review also discusses that various other factors are involved in the remodeling of the extracellular matrix in response to loading, and that parameters like an inflammatory environment might influence the biological response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bleuel, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaucke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueggemann, Gert-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehoff, Anja UNSPECIFIED orcid.org/0000-0002-4165-0929 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-409430
DOI:	10.1371/journal.pone.0119816
Journal or Publication Title:	PLoS One
Volume:	10
Number:	3
Date:	2015
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NECROSIS-FACTOR-ALPHA; PROINFLAMMATORY GENE INDUCTION; ARTICULAR-CARTILAGE; GROWTH-FACTOR; NITRIC-OXIDE; II COLLAGEN; PROTEOGLYCAN SYNTHESIS; BOVINE CHONDROCYTES; MECHANICAL STRAIN; TISSUE STRAIN Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40943