Universität zu Köln

Koenecke, Christian ORCID: 0000-0001-7025-1735, Goehring, Gudrun, de Wreede, Liesbeth C., van Biezen, Anja, Scheid, Christof, Volin, Liisa ORCID: 0000-0002-9731-8335, Maertens, Johan, Finke, Juergen, Schaap, Nicolaas ORCID: 0000-0001-7696-4752, Robin, Marie ORCID: 0000-0003-1388-9876, Passweg, Jakob, Cornelissen, Jan, Beelen, Dietrich ORCID: 0000-0001-5050-220X, Heuser, Michael ORCID: 0000-0001-5318-9044, de Witte, Theo and Kroeger, Nicolaus (2015). Impact of the revised International Prognostic Scoring System, cytogenetics and monosomal karyotype on outcome after allogeneic stem cell transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia evolving from myelodysplastic syndromes: a retrospective multicenter study of the European Society of Blood and Marrow Transplantation. Haematologica, 100 (3). S. 400 - 409. PAVIA: FERRATA STORTI FOUNDATION. ISSN 0390-6078

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Abstract

The aim of this study was to determine the impact of the revised 5-group International Prognostic Scoring System cytogenetic classification on outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia who were reported to the European Society for Blood and Marrow Transplantation database. A total of 903 patients had sufficient cytogenetic information available at stem cell transplantation to be classified according to the 5-group classification. Poor and very poor risk according to this classification was an independent predictor of shorter relapse-free survival (hazard ratio 1.40 and 2.14), overall survival (hazard ratio 1.38 and 2.14), and significantly higher cumulative incidence of relapse (hazard ratio 1.64 and 2.76), compared to patients with very good, good or intermediate risk. When comparing the predictive performance of a series of Cox models both for relapse-free survival and for overall survival, a model with simplified 5-group cytogenetics (merging very good, good and intermediate cytogenetics) performed best. Furthermore, monosomal karyotype is an additional negative predictor for outcome within patients of the poor, but not the very poor risk group of the 5-group classification. The revised International Prognostic Scoring System cytogenetic classification allows patients with myelodysplastic syndromes to be separated into three groups with clearly different outcomes after stem cell transplantation. Poor and very poor risk cytogenetics were strong predictors of poor patient outcome. The new cytogenetic classification added value to prediction of patient outcome compared to prediction models using only traditional risk factors or the 3-group International Prognostic Scoring System cytogenetic classification.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koenecke, Christian UNSPECIFIED orcid.org/0000-0001-7025-1735 UNSPECIFIED Goehring, Gudrun UNSPECIFIED UNSPECIFIED UNSPECIFIED de Wreede, Liesbeth C. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Biezen, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Volin, Liisa UNSPECIFIED orcid.org/0000-0002-9731-8335 UNSPECIFIED Maertens, Johan UNSPECIFIED UNSPECIFIED UNSPECIFIED Finke, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaap, Nicolaas UNSPECIFIED orcid.org/0000-0001-7696-4752 UNSPECIFIED Robin, Marie UNSPECIFIED orcid.org/0000-0003-1388-9876 UNSPECIFIED Passweg, Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornelissen, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Beelen, Dietrich UNSPECIFIED orcid.org/0000-0001-5050-220X UNSPECIFIED Heuser, Michael UNSPECIFIED orcid.org/0000-0001-5318-9044 UNSPECIFIED de Witte, Theo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Nicolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-410816
DOI:	10.3324/haematol.2014.116715
Journal or Publication Title:	Haematologica
Volume:	100
Number:	3
Page Range:	S. 400 - 409
Date:	2015
Publisher:	FERRATA STORTI FOUNDATION
Place of Publication:	PAVIA
ISSN:	0390-6078
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HLA-IDENTICAL SIBLINGS; DE-NOVO; IPSS-R; MDS; RISK; CLASSIFICATION; CHEMOTHERAPY; AML; SURVIVAL; THERAPY Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41081