Amft, Maren, Bzdok, Danilo, Laird, Angela R., Fox, Peter T., Schilbach, Leonhard ORCID: 0000-0001-5547-8309 and Eickhoff, Simon B.
ORCID: 0000-0001-6363-2759
(2015).
Definition and characterization of an extended social-affective default network.
Brain Struct. Funct., 220 (2).
S. 1031 - 1050.
HEIDELBERG:
SPRINGER HEIDELBERG.
ISSN 1863-2661
Abstract
Recent evidence suggests considerable overlap between the default mode network (DMN) and regions involved in social, affective and introspective processes. We considered these overlapping regions as the social-affective part of the DMN. In this study, we established a robust mapping of the underlying brain network formed by these regions and those strongly connected to them (the extended social-affective default network). We first seeded meta-analytic connectivity modeling and resting-state analyses in the meta-analytically defined DMN regions that showed statistical overlap with regions associated with social and affective processing. Consensus connectivity of each seed was subsequently delineated by a conjunction across both connectivity analyses. We then functionally characterized the ensuing regions and performed several cluster analyses. Among the identified regions, the amygdala/hippocampus formed a cluster associated with emotional processes and memory functions. The ventral striatum, anterior cingulum, subgenual cingulum and ventromedial prefrontal cortex formed a heterogeneous subgroup associated with motivation, reward and cognitive modulation of affect. Posterior cingulum/precuneus and dorsomedial prefrontal cortex were associated with mentalizing, self-reference and autobiographic information. The cluster formed by the temporo-parietal junction and anterior middle temporal sulcus/gyrus was associated with language and social cognition. Taken together, the current work highlights a robustly interconnected network that may be central to introspective, socio-affective, that is, self- and other-related mental processes.
Item Type: | Journal Article | ||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-411594 | ||||||||||||||||||||||||||||
DOI: | 10.1007/s00429-013-0698-0 | ||||||||||||||||||||||||||||
Journal or Publication Title: | Brain Struct. Funct. | ||||||||||||||||||||||||||||
Volume: | 220 | ||||||||||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||||||||||
Page Range: | S. 1031 - 1050 | ||||||||||||||||||||||||||||
Date: | 2015 | ||||||||||||||||||||||||||||
Publisher: | SPRINGER HEIDELBERG | ||||||||||||||||||||||||||||
Place of Publication: | HEIDELBERG | ||||||||||||||||||||||||||||
ISSN: | 1863-2661 | ||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||
Uncontrolled Keywords: |
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URI: | http://kups.ub.uni-koeln.de/id/eprint/41159 |
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