Universität zu Köln

Mendes, Tasha K., Novakovic, Stevan ORCID: 0000-0002-9823-6411, Raymant, Greta, Bertram, Sonja E., Esmaillie, Reza, Nadarajan, Saravanapriah, Breugelmans, Bert, Hofmann, Andreas ORCID: 0000-0003-4408-5467, Gasser, Robin B., Colaiacovo, Monica P. and Boag, Peter R. (2015). Investigating the Role of RIO Protein Kinases in Caenorhabditis elegans. PLoS One, 10 (2). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

RIO protein kinases (RIOKs) are a relatively conserved family of enzymes implicated in cell cycle control and ribosomal RNA processing. Despite their functional importance, they remain a poorly understood group of kinases in multicellular organisms. Here, we show that the C. elegans genome contains one member of each of the three RIOK sub-families and that each of the genes coding for them has a unique tissue expression pattern. Our analysis showed that the gene encoding RIOK-1 (riok-1) was broadly and strongly expressed. Interestingly, the intestinal expression of riok-1 was dependent upon two putative binding sites for the oxidative and xenobiotic stress response transcription factor SKN-1. RNA interference (RNAi)-mediated knock down of riok-1 resulted in germline defects, including defects in germ line stem cell proliferation, oocyte maturation and the production of endomitotic oocytes. Taken together, our findings indicate new functions for RIOK-1 in post mitotic tissues and in reproduction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mendes, Tasha K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Novakovic, Stevan UNSPECIFIED orcid.org/0000-0002-9823-6411 UNSPECIFIED Raymant, Greta UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertram, Sonja E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Esmaillie, Reza UNSPECIFIED UNSPECIFIED UNSPECIFIED Nadarajan, Saravanapriah UNSPECIFIED UNSPECIFIED UNSPECIFIED Breugelmans, Bert UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofmann, Andreas UNSPECIFIED orcid.org/0000-0003-4408-5467 UNSPECIFIED Gasser, Robin B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Colaiacovo, Monica P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boag, Peter R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-412318
DOI:	10.1371/journal.pone.0117444
Journal or Publication Title:	PLoS One
Volume:	10
Number:	2
Date:	2015
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRE-RIBOSOMAL-RNA; FAMILY; MATURATION; SKN-1 Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41231