Universität zu Köln

Caroli, Anna ORCID: 0000-0002-4130-4663, Prestia, Annapaola, Galluzzi, Samantha ORCID: 0000-0001-9804-5669, Ferrari, Clarissa ORCID: 0000-0002-4101-6872, van der Flier, Wiesje M., Ossenkoppele, Rik, Van Berckel, Bart, Barkhof, Frederik ORCID: 0000-0003-3543-3706, Teunissen, Charlotte, Wall, Anders E., Carter, Stephen F. ORCID: 0000-0002-9080-519X, Schoell, Michael, Choo, Il Han, Grimmer, Timo, Redolfi, Alberto ORCID: 0000-0002-4145-9059, Nordberg, Agneta ORCID: 0000-0001-7345-5151, Scheltens, Philip ORCID: 0000-0002-1046-6408, Drzezga, Alexander and Frisoni, Giovanni B. (2015). Mild cognitive impairment with suspected nonamyloid pathology (SNAP) Prediction of progression. Neurology, 84 (5). S. 508 - 516. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1526-632X

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Abstract

Objectives:The aim of this study was to investigate predictors of progressive cognitive deterioration in patients with suspected non-Alzheimer disease pathology (SNAP) and mild cognitive impairment (MCI).Methods:We measured markers of amyloid pathology (CSF -amyloid 42) and neurodegeneration (hippocampal volume on MRI and cortical metabolism on [F-18]-fluorodeoxyglucose-PET) in 201 patients with MCI clinically followed for up to 6 years to detect progressive cognitive deterioration. We categorized patients with MCI as A+/A- and N+/N- based on presence/absence of amyloid pathology and neurodegeneration. SNAPs were A-N+ cases.Results:The proportion of progressors was 11% (8/41), 34% (14/41), 56% (19/34), and 71% (60/85) in A-N-, A+N-, SNAP, and A+N+, respectively; the proportion of APOE epsilon 4 carriers was 29%, 70%, 31%, and 71%, respectively, with the SNAP group featuring a significantly different proportion than both A+N- and A+N+ groups (p 0.005). Hypometabolism in SNAP patients was comparable to A+N+ patients (p = 0.154), while hippocampal atrophy was more severe in SNAP patients (p = 0.002). Compared with A-N-, SNAP and A+N+ patients had significant risk of progressive cognitive deterioration (hazard ratio = 2.7 and 3.8, p = 0.016 and p < 0.001), while A+N- patients did not (hazard ratio = 1.13, p = 0.771). In A+N- and A+N+ groups, none of the biomarkers predicted time to progression. In the SNAP group, lower time to progression was correlated with greater hypometabolism (r = 0.42, p = 0.073).Conclusions:Our findings support the notion that patients with SNAP MCI feature a specific risk progression profile.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Caroli, Anna UNSPECIFIED orcid.org/0000-0002-4130-4663 UNSPECIFIED Prestia, Annapaola UNSPECIFIED UNSPECIFIED UNSPECIFIED Galluzzi, Samantha UNSPECIFIED orcid.org/0000-0001-9804-5669 UNSPECIFIED Ferrari, Clarissa UNSPECIFIED orcid.org/0000-0002-4101-6872 UNSPECIFIED van der Flier, Wiesje M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ossenkoppele, Rik UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Berckel, Bart UNSPECIFIED UNSPECIFIED UNSPECIFIED Barkhof, Frederik UNSPECIFIED orcid.org/0000-0003-3543-3706 UNSPECIFIED Teunissen, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Wall, Anders E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Carter, Stephen F. UNSPECIFIED orcid.org/0000-0002-9080-519X UNSPECIFIED Schoell, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Choo, Il Han UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Redolfi, Alberto UNSPECIFIED orcid.org/0000-0002-4145-9059 UNSPECIFIED Nordberg, Agneta UNSPECIFIED orcid.org/0000-0001-7345-5151 UNSPECIFIED Scheltens, Philip UNSPECIFIED orcid.org/0000-0002-1046-6408 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Frisoni, Giovanni B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-412714
DOI:	10.1212/WNL.0000000000001209
Journal or Publication Title:	Neurology
Volume:	84
Number:	5
Page Range:	S. 508 - 516
Date:	2015
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1526-632X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBROSPINAL-FLUID BIOMARKERS; ALZHEIMERS-DISEASE; NATIONAL INSTITUTE; BETA; RECOMMENDATIONS; ACCURACY; DEMENTIA; MARKERS; TANGLE; PIB Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41271