Universität zu Köln

Sabashnikov, Anton ORCID: 0000-0002-6289-1035, Popov, Aron-Frederik ORCID: 0000-0003-4226-3004, Bowles, Christopher T., Weymann, Alexander, Mohite, Prashant N., Wahlers, Thorsten, Wittwer, Thorsten, Zych, Bartlomiej, Garcia-Saez, Diana, Patil, Nikhil P., Fatullayev, Javid, Amrani, Mohamed, Banner, Nicholas R., Seidler, Tim ORCID: 0000-0002-6158-5087, Unsoeld, Bernhard, Bireta, Christian, Schoendube, Friedrich A. and Simon, Andre R. (2015). First Experience With the Synergy Micro-Pump in Patients in INTERMACS Class 1-2 as a Bridge to Transplantation: Pushing the Limits? Artif. Organs, 39 (2). S. 118 - 126. HOBOKEN: WILEY. ISSN 1525-1594

Full text not available from this repository.

Abstract

The Synergy Micro-pump is the smallest implantable left ventricular assist device (LVAD) and provides partial flow support up to 4.25L/min. It was shown that early intervention with this device can provide substantial benefits to patients with severe heart failure not yet sick enough for a full-support LVAD. However, as it can be inserted via small incisions with no need for sternotomy or cardiopulmonary bypass, it might be beneficial for selected high-risk patients. The aim of this study was to evaluate the efficacy of the Synergy Micro-pump in patients in INTERMACS class 1-2. From February 2012 to August 2013, 13 patients with severe heart failure were supported with the Synergy Pocket Micro-pump. Patients were divided into two groups according to INTERMACS class: the high-risk group (INTERMACS class 1-2) and the low-risk group (INTERMACS class 3-4). There were seven patients in INTERMACS class 1-2 and six in INTERMACS class 3-4. Patient demographics, perioperative characteristics, and postoperative outcomes were compared. There were no statistically significant differences in patient demographics, and mean support time was 108 +/- 114 days in the high-risk group and 238 +/- 198 days in the low-risk group. Also, there were no significant differences in perioperative characteristics or in the rate of postoperative adverse events. The overall survival was comparable between the two groups (one late death in each group, log-rank P=0.608). Two patients from the high-risk group were upgraded to a full-support LVAD (P=0.462) after 65 +/- 84.9 days of mean support. One patient from the high-risk group and two patients from the low-risk group were successfully transplanted (P=0.559). The use of the Synergy Micro-pump in INTERMACS 1-2 patients is feasible and is associated with similar postoperative outcome as in patients in INTERMACS 3-4. Carefully selected patients with severe heart failure could benefit due to the small size of the pump; however, further studies and medium-term follow-up are required.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sabashnikov, Anton UNSPECIFIED orcid.org/0000-0002-6289-1035 UNSPECIFIED Popov, Aron-Frederik UNSPECIFIED orcid.org/0000-0003-4226-3004 UNSPECIFIED Bowles, Christopher T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weymann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohite, Prashant N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittwer, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Zych, Bartlomiej UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Saez, Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED Patil, Nikhil P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fatullayev, Javid UNSPECIFIED UNSPECIFIED UNSPECIFIED Amrani, Mohamed UNSPECIFIED UNSPECIFIED UNSPECIFIED Banner, Nicholas R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidler, Tim UNSPECIFIED orcid.org/0000-0002-6158-5087 UNSPECIFIED Unsoeld, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Bireta, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoendube, Friedrich A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Andre R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-413039
DOI:	10.1111/aor.12316
Journal or Publication Title:	Artif. Organs
Volume:	39
Number:	2
Page Range:	S. 118 - 126
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1525-1594
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTRICULAR ASSIST DEVICE; CIRCULATORY SUPPORT; HEART-FAILURE; IMPLANTATION Multiple languages Engineering, Biomedical; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41303