Universität zu Köln

Bleeker, Gitta, van Eck-Smit, Berthe L., Zwinderman, Koos H., Versteeg, Rogier ORCID: 0000-0001-7172-0388, van Noesel, Max M., Kam, Boen L., Kaspers, Gertjan J., van Schie, Annelies, Kreissman, Susan G., Yanik, Gregory, Hero, Barbara, Schmidt, Matthias, Laureys, Genevieve, Lambert, Bieke, Ora, Ingrid ORCID: 0000-0002-3931-4125, Schulte, Johannes H., Caron, Huib N. and Tytgat, Godelieve A. (2015). MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosis. Eur. J. Nucl. Med. Mol. Imaging, 42 (2). S. 222 - 231. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose The aim of this study was to find clinically relevant MIBG-avid metastatic patterns in patients with newly diagnosed stage 4 neuroblastoma. Methods Diagnostic I-123-MIBG scans from 249 patients (123 from a European and 126 from the COG cohort) were assessed for metastatic spread in 14 body segments and the form of the lesions: focal (clear margins distinguishable from adjacent background) or diffuse (indistinct margins, dispersed throughout the body segment). The total numbers of diffuse and focal lesions were recorded. Patients were then categorized as having lesions exclusively focal, lesions more focal than diffuse, lesions more diffuse than focal, or lesions exclusively diffuse. Results Diffuse lesions affected a median of seven body segments and focal lesions a median of two body segments (P<0.001, both cohorts). Patients with a focal pattern had a median of 2 affected body segments and those with a diffuse pattern a median of 11 affected body segments (P<0.001, both cohorts). Thus, two MIBG-avid metastatic patterns emerged: limited-focal and extensive-diffuse. The median numbers of affected body segments in MYCN-amplified (MNA) tumours were 5 (European cohort) and 4 (COG cohort) compared to 9 and 11, respectively, in single-copy MYCN (MYCNsc) tumours (P<0.001). Patients with exclusively focal metastases were more likely to have a MNA tumour (60 % and 70 %, respectively) than patients with the other types of metastases (23 % and 28 %, respectively; P<0.001). In a multivariate Cox regression analysis, focal metastases were associated with a better event-free and overall survival than the other types of metastases in patients with MNA tumours in the COG cohort (P<0.01). Conclusion Two metastatic patterns were found: a limited and focal pattern found mainly in patients with MNA neuroblastoma that correlated with prognosis, and an extensive and diffuse pattern found mainly in patients with MYCNsc neuroblastoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bleeker, Gitta UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eck-Smit, Berthe L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zwinderman, Koos H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Versteeg, Rogier UNSPECIFIED orcid.org/0000-0001-7172-0388 UNSPECIFIED van Noesel, Max M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kam, Boen L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaspers, Gertjan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Schie, Annelies UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreissman, Susan G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yanik, Gregory UNSPECIFIED UNSPECIFIED UNSPECIFIED Hero, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Laureys, Genevieve UNSPECIFIED UNSPECIFIED UNSPECIFIED Lambert, Bieke UNSPECIFIED UNSPECIFIED UNSPECIFIED Ora, Ingrid UNSPECIFIED orcid.org/0000-0002-3931-4125 UNSPECIFIED Schulte, Johannes H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Caron, Huib N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tytgat, Godelieve A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-413351
DOI:	10.1007/s00259-014-2909-1
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	42
Number:	2
Page Range:	S. 222 - 231
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language I-123 METAIODOBENZYLGUANIDINE SCINTIGRAPHY; EVENT-FREE SURVIVAL; FOLLOW-UP; DIAGNOSIS; CHILDREN; CHEMOTHERAPY; PREDICTION; GUIDELINES; CRITERIA; THERAPY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41335