Universität zu Köln

Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Vandenabeele, Peter ORCID: 0000-0002-6669-8822 (2015). Necroptosis and its role in inflammation. Nature, 517 (7534). S. 311 - 321. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

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Abstract

Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires the proteins RIPK3 and MLKL and is induced by death receptors, interferons, toll-like receptors, intracellular RNA and DNA sensors, and probably other mediators. RIPK1 has important kinase-dependent and scaffolding functions that inhibit or trigger necroptosis and apoptosis. Mouse-model studies have revealed important functions for necroptosis in inflammation and suggested that it could be implicated in the pathogenesis of many human inflammatory diseases. We discuss the mechanisms regulating necroptosis and its potential role in inflammation and disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pasparakis, Manolis UNSPECIFIED orcid.org/0000-0002-9870-0966 UNSPECIFIED Vandenabeele, Peter UNSPECIFIED orcid.org/0000-0002-6669-8822 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-414640
DOI:	10.1038/nature14191
Journal or Publication Title:	Nature
Volume:	517
Number:	7534
Page Range:	S. 311 - 321
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-4687
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RECEPTOR-INTERACTING PROTEIN; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; NF-KAPPA-B; CELL-DEATH; PROGRAMMED NECROSIS; RIP1 KINASE; EPIDERMAL-KERATINOCYTES; IN-VIVO; CASPASE-8 Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/41464