Universität zu Köln

Kutsch, Nadine, Marks, Reinhard, Ratei, Richard, Held, Thomas K. and Schmidt-Hieber, Martin (2015). Role of Tyrosine Kinase Inhibitors in Indolent and Other Mature B-Cell Neoplasms. Biomark. Insights, 10. S. 15 - 24. LONDON: SAGE PUBLICATIONS LTD. ISSN 1177-2719

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Abstract

Targeting tyrosine kinases represents a highly specific treatment approach for different malignancies. This also includes non-Hodgkin lymphoma since it is well known that these enzymes are frequently involved in the lymphomagenesis. Hereby, tyrosine kinases might either be dysregulated intrinsically or be activated within signal transduction pathways leading to tumor survival and growth. Among others, Bruton's tyrosine kinase (Btk) is of particular interest as a potential therapeutic target. Btk is stimulated by B-cell receptor signaling and activates different transcription factors such as nuclear factor kappa B. The Btk inhibitor ibrutinib has been approved for the treatment of chronic lymphocytic leukemia and mantle-cell lymphoma recently. Numerous clinical trials evaluating this agent in different combinations (eg, with rituximab or classical chemotherapeutic agents) as a treatment option for aggressive and indolent lymphoma are under way. Here, we summarize the role of tyrosine kinase inhibitors in the treatment of indolent and other non-Hodgkin lymphomas (eg, mantle-cell lymphoma).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kutsch, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Marks, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Ratei, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Held, Thomas K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt-Hieber, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-415281
DOI:	10.4137/BMI.S22434
Journal or Publication Title:	Biomark. Insights
Volume:	10
Page Range:	S. 15 - 24
Date:	2015
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1177-2719
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC LYMPHOCYTIC-LEUKEMIA; GROWTH-FACTOR RECEPTOR-3; NON-HODGKIN-LYMPHOMA; MULTIPLE-MYELOMA MODEL; PHASE-II; OPEN-LABEL; FOLLICULAR LYMPHOMA; IBRUTINIB PCI-32765; TUMOR PROGRESSION; TREATMENT-NAIVE Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41528