Universität zu Köln

Zwart, Mark P. and Elena, Santiago F. ORCID: 0000-0001-8249-5593 (2015). Matters of Size: Genetic Bottlenecks in Virus Infection and Their Potential Impact on Evolution. In: Annual Review of Virology, S. 161 - 180. PALO ALTO: ANNUAL REVIEWS. ISBN 978-0-8243-3402-4

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Abstract

For virus infections of multicellular hosts, narrow genetic bottlenecks during transmission and within-host spread appear to be widespread. These bottlenecks will affect the maintenance of genetic variation in a virus population and the prevalence of mixed-strain infections, thereby ultimately determining the strength with which different random forces act during evolution. Here we consider different approaches for estimating bottleneck sizes and weigh their merits. We then review quantitative estimates of bottleneck size during cellular infection, within-host spread, horizontal transmission, and finally vertical transmission. In most cases we find that bottlenecks do regularly occur, although in many cases they appear to be virion-concentration dependent. Finally, we consider the evolutionary implications of genetic bottlenecks during virus infection. Although on average strong bottlenecks will lead to declines in fitness, we consider a number of scenarios in which bottlenecks could also be advantageous for viruses.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Zwart, Mark P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elena, Santiago F. UNSPECIFIED orcid.org/0000-0001-8249-5593 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-415577
DOI:	10.1146/annurev-virology-100114-055135
Title of Book:	Annual Review of Virology
Volume:	2
Page Range:	S. 161 - 180
Date:	2015
Publisher:	ANNUAL REVIEWS
Place of Publication:	PALO ALTO
ISSN:	2327-056X
ISBN:	978-0-8243-3402-4
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLANT RNA VIRUS; INDEPENDENT ACTION HYPOTHESIS; TOBACCO-MOSAIC-VIRUS; SPOT SYNDROME VIRUS; VERTICAL TRANSMISSION; VIRAL POPULATION; TRICHOPLUSIA-NI; SIGN EPISTASIS; MULLER RATCHET; INSECT VIRUS Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41557