Doulgere, Julia, Otto, Benjamin, Nassour, Maher, Wolters-Eisfeld, Gerrit ORCID: 0000-0002-2984-6515, Rohde, Holger ORCID: 0000-0001-8587-4433, Magnus, Tim, Wagener, Christoph and Streichert, Thomas (2015). Soluble plasma VE-cadherin concentrations are elevated in patients with STEC infection and haemolytic uraemic syndrome: a case-control study. BMJ Open, 5 (3). LONDON: BMJ PUBLISHING GROUP. ISSN 2044-6055

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Abstract

Objectives: To investigate whether the adherens junction protein vascular endothelial cadherin (VE-cadherin) is released during Shiga toxin 2 producing Escherichia coli (STEC) infection with haemolytic uraemic syndrome (HUS) and thus could be used to assist diagnosis. Design: Using data from the large 2011 STEC outbreak in northern Europe, we determined VE-cadherin plasma concentrations in 356 patients distributed over three patient cohorts: patients with STEC infection accompanied by HUS (STEC-HUS), STEC patients without HUS (STEC) and control patients with diarrhoea but without STEC infection. We then looked for associations between VE-cadherin concentrations and disease severity defined by changes in lactate dehydrogenase, haemoglobin, creatinine, platelet count, haptoglobin and neurological symptoms. Setting: This study was conducted at the University Medical Center Hamburg-Eppendorf, Germany. Participants: 79 STEC-HUS patients, 77 STEC patients and 200 control patients were enrolled in the study. Results: We analysed 864 specimens (207 STEC, 449 STEC-HUS and 208 controls) in total. At admission, VE-cadherin concentration tended to be lower in STEC-HUS patients compared to other patients. However, HUS patients later showed an increase in VE-cadherin concentrations with prolonged elevation beyond remission. This pattern clearly differs from that observed in non-HUS patients. Conclusions: VE-cadherin concentrations are elevated in STEC-HUS patients and might be a biomarker reflecting endothelial damage in patients with HUS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Doulgere, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Otto, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nassour, MaherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolters-Eisfeld, GerritUNSPECIFIEDorcid.org/0000-0002-2984-6515UNSPECIFIED
Rohde, HolgerUNSPECIFIEDorcid.org/0000-0001-8587-4433UNSPECIFIED
Magnus, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagener, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Streichert, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-415690
DOI: 10.1136/bmjopen-2014-005659
Journal or Publication Title: BMJ Open
Volume: 5
Number: 3
Date: 2015
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2044-6055
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VASCULAR ENDOTHELIAL-CADHERIN; ESCHERICHIA-COLI INFECTIONS; CELLS; SEPSIS; PERMEABILITYMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41569

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