Universität zu Köln

Reichwagen, Annegret, Ziepert, Marita, Kreuz, Markus ORCID: 0000-0002-0520-8391, Goedtel-Armbrust, Ute, Rixecker, Tanja, Poeschel, Viola, Toliat, Mohammad Reza, Nuernberg, Peter, Tzvetkov, Mladen, Deng, Shiwei, Truemper, Lorenz, Hasenfuss, Gerd, Pfreundschuh, Michael and Wojnowski, Leszek (2015). Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma. Pharmacogenomics, 16 (4). S. 361 - 373. LONDON: FUTURE MEDICINE LTD. ISSN 1744-8042

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Abstract

Aim: To identify gene variants responsible for anthracycline-induced cardiotoxicity. Patients & methods: Polymorphisms of the NADPH oxidase subunits and of the anthracycline transporters ABCC1, ABCC2 and SLC28A3 were genotyped in elderly patients (61-80 years) treated for aggressive CD20(+) B-cell lymphomas with CHOP-14 with or without rituximab and followed up for 3 years. Results: The accumulation of RAC2 subunit genotypes TA/AA among cases was statistically significant upon adjustment for gender, age and doxorubicin dose in a multivariate logistic regression analysis (OR: 2.3, p = 0.028; univariate: OR: 1.8, p = 0.077). RAC2 and CYBA genotypes were significantly associated with anthracycline-induced cardiotoxicity in a meta-analysis of this and a similar previous study. Conclusion: Our results support the theory that NADPH oxidase is involved in anthracycline-induced cardiotoxicity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reichwagen, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziepert, Marita UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuz, Markus UNSPECIFIED orcid.org/0000-0002-0520-8391 UNSPECIFIED Goedtel-Armbrust, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Rixecker, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Poeschel, Viola UNSPECIFIED UNSPECIFIED UNSPECIFIED Toliat, Mohammad Reza UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuernberg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Tzvetkov, Mladen UNSPECIFIED UNSPECIFIED UNSPECIFIED Deng, Shiwei UNSPECIFIED UNSPECIFIED UNSPECIFIED Truemper, Lorenz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasenfuss, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfreundschuh, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wojnowski, Leszek UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-416893
DOI:	10.2217/PGS.14.179
Journal or Publication Title:	Pharmacogenomics
Volume:	16
Number:	4
Page Range:	S. 361 - 373
Date:	2015
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1744-8042
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENETIC POLYMORPHISMS; NAD(P)H OXIDASE; DOXORUBICIN; EXPRESSION; PREDICTION; TOXICITY; VARIANT Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41689