Universität zu Köln

Maegele, M., Braun, M., Wafaisade, A., Schaefer, N., Lippert-Gruener, M., Kreipke, C., Rafols, J., Schaefer, U., Angelov, D. N. and Stuermer, E. K. (2015). Long-Term Effects of Enriched Environment on Neurofunctional Outcome and CNS Lesion Volume After Traumatic Brain Injury in Rats. Physiol. Res., 64 (1). S. 129 - 146. PRAGUE 4: ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY. ISSN 1802-9973

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Abstract

To determine whether the exposure to long term enriched environment (EE) would result in a continuous improvement of neurological recovery and ameliorate the loss of brain tissue after traumatic brain injury (TBI) vs. standard housing (SH). Male Sprague-Dawley rats (300-350 g, n=28) underwent lateral fluid percussion brain injury or SHAM operation. One TBI group was held under complex EE for 90 days, the other under SH. Neuromotor and sensorimotor dysfunction and recovery were assessed after injury and at days 7, 15, and 90 via Composite Neuroscore (NS), RotaRod test, and Barnes Circular Maze (BCM). Cortical tissue loss was assessed using serial brain sections. After day 7 EE animals showed similar latencies and errors as SHAM in the BCM. SH animals performed notably worse with differences still significant on day 90 (p<0.001). RotaRod test and NS revealed superior results for EE animals after day 7. The mean cortical volume was significantly higher in EE vs. SH animals (p=0.003). In summary, EE animals after lateral fluid percussion (LFP) brain injury performed significantly better than SH animals after 90 days of recovery. The window of opportunity may be wide and also lends further credibility to the importance of long term interventions in patients suffering from TBI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maegele, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wafaisade, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lippert-Gruener, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreipke, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rafols, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, D. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuermer, E. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-417136
DOI:	10.33549/physiolres.932664
Journal or Publication Title:	Physiol. Res.
Volume:	64
Number:	1
Page Range:	S. 129 - 146
Date:	2015
Publisher:	ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
Place of Publication:	PRAGUE 4
ISSN:	1802-9973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FLUID PERCUSSION INJURY; MEDIATED FUNCTIONAL IMPROVEMENT; NEURON-SPECIFIC ENOLASE; EARLY-ONSET STIMULATION; FACTOR MESSENGER-RNA; DENTATE GYRUS; COGNITIVE RECOVERY; MOTOR DEFICITS; VISUAL-CORTEX; STEREOLOGICAL METHODS Multiple languages Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41713