Universität zu Köln

Holtick, Udo, Frenzel, Lukas P., Shimabukuro-Vornhagen, Alexander ORCID: 0000-0002-2351-7294, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Claasen, Julia, Scheid, Christof, von Bergwelt-Baildon, Michael, Froehlich, Holger, Wendtner, Clemens M. and Chemnitz, Jens M. (2015). CD4+T cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation. Ann. Hematol., 94 (1). S. 129 - 138. NEW YORK: SPRINGER. ISSN 1432-0584

Full text not available from this repository.

Abstract

The recovery of the host immune system after allogeneic hematopoietic stem cell transplantation is pivotal to prevent infections, relapse, and secondary malignancies. In particular, numerical CD4+ T cells reconstitution is delayed and CD4 helper cell function is considered impaired as a consequence of the transplant procedure and concomitant immunosuppressive medication. From HIV/AIDS patients, it is known that numerical and functional CD4 defects increase the risk of opportunistic infections. However, and in contrast to patients with HIV, anti-infective prophylaxis after allogeneic transplantation is usually given for 6 months depending on immunosuppressive medication and existing graft-versus-host disease but independently of absolute CD4+ T cells counts. We hypothesized that a qualitative T cell defect is existing after allogeneic transplantation, especially in patients with delayed immune-reconstitution. Applying transcriptional as well as functional approaches, we show that CD4+ T cells with delayed recovery have a distinct transcriptional profile and cluster differently from T cells originated from patients with completed immune recovery. Moreover, inhibitory signatures are substantially enriched within the transcriptional profile of these T cells translating to functional defects and impaired interleukin 2 production. In addition to time after transplant, CD4+ T cells numbers should be considered for the decision to stop or maintain antimicrobial prophylaxis in patients after allogeneic stem cell transplantation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Holtick, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Frenzel, Lukas P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shimabukuro-Vornhagen, Alexander UNSPECIFIED orcid.org/0000-0002-2351-7294 UNSPECIFIED Theurich, Sebastian UNSPECIFIED orcid.org/0000-0001-5706-8258 UNSPECIFIED Claasen, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Froehlich, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Wendtner, Clemens M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chemnitz, Jens M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-417903
DOI:	10.1007/s00277-014-2166-1
Journal or Publication Title:	Ann. Hematol.
Volume:	94
Number:	1
Page Range:	S. 129 - 138
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0584
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BONE-MARROW-TRANSPLANTATION; INFECTIOUS-DISEASES SOCIETY; HIV MEDICINE ASSOCIATION; INSTITUTES-OF-HEALTH; IMMUNE RECONSTITUTION; OPPORTUNISTIC INFECTIONS; T-CELLS; GUIDELINES; RECOMMENDATIONS; COMPLICATIONS Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41790