Universität zu Köln

Cornely, Oliver A., Meems, Lambertus, Herbrecht, Raoul ORCID: 0000-0002-9381-4876, Viscoli, Claudio, van Amsterdam, Ronald G. M. and Ruhnke, Markus (2015). Randomised, multicentre trial of micafungin vs. an institutional standard regimen for salvage treatment of invasive aspergillosis. Mycoses, 58 (1). S. 58 - 65. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Invasive aspergillosis remains associated with significant morbidity and mortality, necessitating new options for salvage therapy. The objective of this study was to evaluate the efficacy and safety of micafungin as salvage monotherapy in patients with invasive aspergillosis. Patients with proven or probable invasive aspergillosis, who were refractory or intolerant to previous systemic antifungal therapy, were randomised 2:1 to receive 300mgday(-1) intravenous micafungin monotherapy or an intravenous control monotherapy [lipid amphotericin B (5mgkg(-1)day(-1)), voriconazole (8mgkg(-1)day(-1)) or caspofungin (50mgday(-1))] for 3-12weeks. Patients underwent final assessment 12weeks after treatment start. Seventeen patients with invasive aspergillosis (proven, n=2; probable, n=14; not recorded, n=1) participated in the study (micafungin arm, n=12; control arm, n=5). Three patients each in the micafungin (25.0%; 95% CI: 5.5-57.2) and control arm (60.0%; 95% CI: 14.7-94.7) had successful therapy at end of treatment as assessed by an Independent Data Review Board. Eleven patients died; six due to invasive aspergillosis. No deaths were considered related to study treatment. During this study it became increasingly common to use combination treatment for salvage therapy. Consequently, enrolment was low and the study was discontinued early. No clear trends in efficacy and safety can be concluded.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meems, Lambertus UNSPECIFIED UNSPECIFIED UNSPECIFIED Herbrecht, Raoul UNSPECIFIED orcid.org/0000-0002-9381-4876 UNSPECIFIED Viscoli, Claudio UNSPECIFIED UNSPECIFIED UNSPECIFIED van Amsterdam, Ronald G. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhnke, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-418028
DOI:	10.1111/myc.12274
Journal or Publication Title:	Mycoses
Volume:	58
Number:	1
Page Range:	S. 58 - 65
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIPOSOMAL AMPHOTERICIN-B; COMBINATION ANTIFUNGAL THERAPY; HEMATOLOGIC MALIGNANCIES; TRANSPLANT PATIENTS; EFFICACY; VORICONAZOLE; CASPOFUNGIN; INFECTIONS; SOCIETY; EPIDEMIOLOGY Multiple languages Dermatology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41802