Universität zu Köln

Adam, Alexander C., Scriba, Alexander, Ortmann, Monika, Huss, Sebastian, Kahl, Philip, Steiner, Susanne, Stoerkel, Stephan and Buettner, Reinhard (2015). Immunohistochemical Analysis of Cytochrome c Oxidase Facilitates Differentiation Between Oncocytoma and Chromophobe Renal Cell Carcinoma. Appl. Immunohistochem., 23 (1). S. 54 - 60. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1533-4058

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Abstract

In this study, immunohistochemical staining pattern of cytochrome c oxidase subunit 1 (CCO1) was investigated in the differentiation of renal oncocytoma (RO) from eosinophilic (EoC) and classic chromophobe renal cell carcinoma (ChRCC). A feature found in ChRCC/EoC but not in RO is the predominance of a perinuclear halo when stained for CCO1. In a cohort of 103 mixed cases including 44 RO, 37 classic ChRCC and 22 EoC, the diagnosis based on this immunohistochemical feature alone was consistent with the previous routine diagnosis in 95.7%. We reached 100% specificity and 81.4% sensitivity of this pattern in ChRCC. Specificity for RO was 93.2% and sensitivity correspondingly 95.5%. We propose a novel and easily interpretable immunohistochemical method for the discrimination of benign RO from certain subtypes of malignant ChRCC. Because of strong similarity in morphology of the 2 entities the diagnosis often cannot be made based on standard histopathology alone. The study describes for the first time the formation of a perinuclear halo in CCO1 immunohistochemistry as a highly specific marker for the diagnosis of ChRCC. We think this method can be a strong amendment for routine diagnostics in renal cell carcinoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Adam, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scriba, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Ortmann, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Huss, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kahl, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED Steiner, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoerkel, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-418223
DOI:	10.1097/PAI.0000000000000036
Journal or Publication Title:	Appl. Immunohistochem.
Volume:	23
Number:	1
Page Range:	S. 54 - 60
Date:	2015
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1533-4058
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPITHELIAL NEOPLASMS; HEIDELBERG CLASSIFICATION; EOSINOPHILIC VARIANT; HISTOLOGIC SUBTYPES; DIAGNOSIS; UTILITY; TUMORS; CLEAR; CYTOKERATIN-7; MITOCHONDRIA Multiple languages Anatomy & Morphology; Medical Laboratory Technology; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41822