Universität zu Köln

Grund, Sebastian, Gkioule, Charikleia, Termos, Tahani, Pfeifer, Nico ORCID: 0000-0002-4647-8566, Kobbe, Guido, Verheyen, Jens and Adams, Ortwin (2015). Primarily oseltamivir-resistant influenza A (H1N1pdm09) virus evolving into a multidrug-resistant virus carrying H275Y and I223R neuraminidase substitutions. Antivir. Ther., 20 (1). S. 97 - 101. LONDON: INT MEDICAL PRESS LTD. ISSN 1359-6535

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Abstract

Antiviral susceptibility testing and reporting of viruses carrying amino acid substitutions conferring antiviral drug resistance is essential to assess the spread and clinical impact of these viruses. Here, we report on a patient who was infected with a primarily oseltamivir-resistant influenza A (H1N1pdm09) virus following allogeneic stem cell transplantation and rituximab treatment. Under prolonged virus replication and zanamivir therapy the neuraminidase amino acid substitutions H275Y and I223R were detected conferring high-level resistance to oseltamivir and cross-resistance to zanamivir. The emergence of these amino acid changes has been reported rarely worldwide and has been associated with fatal clinical outcomes. The patient survived the influenza infection after 170 days of follow-up.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grund, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Gkioule, Charikleia UNSPECIFIED UNSPECIFIED UNSPECIFIED Termos, Tahani UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeifer, Nico UNSPECIFIED orcid.org/0000-0002-4647-8566 UNSPECIFIED Kobbe, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Verheyen, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Adams, Ortwin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-418371
DOI:	10.3851/IMP2811
Journal or Publication Title:	Antivir. Ther.
Volume:	20
Number:	1
Page Range:	S. 97 - 101
Date:	2015
Publisher:	INT MEDICAL PRESS LTD
Place of Publication:	LONDON
ISSN:	1359-6535
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PANDEMIC H1N1 2009; UNITED-STATES; INFECTION; MUTATION Multiple languages Infectious Diseases; Pharmacology & Pharmacy; Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41837