Universität zu Köln

Kuhn, Elmar W., Choi, Yeong-Hoon, Pyun, Jung-Min, Neef, Klaus, Liakopoulos, Oliver J., Stamm, Christof, Wittwer, Thorsten and Wahlers, Thorsten (2015). Endothelial Injury Associated with Cold or Warm Blood Cardioplegia during Coronary Artery Bypass Graft Surgery. Biomed Res. Int., 2015. LONDON: HINDAWI LTD. ISSN 2314-6141

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Abstract

The aim of this investigation was to analyze the impact of intermittent cold blood cardioplegia (ICC) and intermittent warm blood cardioplegia (IWC) on endothelial injury in patients referred to elective on-pump coronary artery bypass graft (CABG) surgery. Patients undergoing CABG procedures were randomized to either ICC or IWC. Myocardial injury was assessed by CK-MB and cardiac troponin T (cTnT). Endothelial injury was quantified by circulating endothelial cells (CECs), von Willebrand factor (vWF), and soluble thrombomodulin (sTM). Perioperative myocardial injury (PMI) and major adverse cardiac events (MACE) were recorded. Demographic data and preoperative risk profile of included patients (ICC: n = 32, IWC: n = 36) were comparable. No deaths, PMI, or MACE were observed. Levels of CK-MB and cTnT did not show intergroup differences. Concentrations of CECs peaked at 6 h postoperatively with significantly higher values for IWC-patients at 1 h (ICC: 10.1 +/- 3.9/mL; IWC: 18.4 +/- 4.1/mL; P = 0.012) and 6h (ICC: 19.3 +/- 6.2/mL; IWC: 29.2 +/- 6.7/mL; P < 0.001). Concentrations of vWF (ICC: 178.4 +/- 73.2 U/dL; IWC: 258.2 +/- 89.7 U/dL; P < 0.001) and sTM (ICC: 3.2 +/- 2.1 ng/mL; IWC: 5.2 +/- 2.4 ng/mL; P = 0.011) were significantly elevated in IWC-group at 1 h postoperatively. This study shows that the use of IWC is associated with a higher extent of endothelial injury compared to ICC without differences in clinical endpoints.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuhn, Elmar W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Choi, Yeong-Hoon UNSPECIFIED UNSPECIFIED UNSPECIFIED Pyun, Jung-Min UNSPECIFIED UNSPECIFIED UNSPECIFIED Neef, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Liakopoulos, Oliver J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stamm, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittwer, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-418418
DOI:	10.1155/2015/256905
Journal or Publication Title:	Biomed Res. Int.
Volume:	2015
Date:	2015
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2314-6141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIOPULMONARY BYPASS; MYOCARDIAL PROTECTION; CARDIAC-SURGERY; CELLS; MARKERS; DAMAGE Multiple languages Biotechnology & Applied Microbiology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41841