Laske, Christoph, Sohrabi, Hamid R., Jasielec, Mateusz S., Mueller, Stephan, Koehler, Niklas K., Graeber, Susanne, Foerster, Stefan, Drzezga, Alexander, Mueller-Sarnowski, Felix, Danek, Adrian ORCID: 0000-0001-8857-5383, Jucker, Mathias, Bateman, Randall J., Buckles, Virginia, Saykin, Andrew J., Martins, Ralph N. and Morris, John C. (2015). Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer's Disease: Results of the DIAN Study. Biomed Res. Int., 2015. LONDON: HINDAWI LTD. ISSN 2314-6141

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Abstract

Objective. We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer's disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN). Methods. The baseline sample of 183 mutation carriers (MCs) and 117 noncarriers (NCs) was divided according to Clinical Dementia Rating (CDR) scale into preclinical (CDR 0; MCs: n = 107; NCs: n = 109), early symptomatic (CDR 0.5; MCs: n = 48; NCs: n = 8), and dementia stage (CDR >= 1; MCs: n = 28; NCs: n = 0). These groups were subdivided by the presence or absence of SMCs. Results. At CDR 0, SMCs were present in 12.1% of MCs and 9.2% of NCs (p = 0.6). At CDR 0.5, SMCs were present in 66.7% of MCs and 62.5% of NCs (p = 1.0). At CDR >= 1, SMCs were present in 96.4% of MCs. SMCs inMCs were significantly associated with CDR, logical memory scores, Geriatric Depression Scale, education, and estimated years to onset. Conclusions. The present study shows that SMCs assessed by a single-item scale have no diagnostic value to identify preclinical ADAD in asymptomatic individuals. These results demonstrate the need of further improvement of SMCmeasures that should be examined in large clinical trials.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sohrabi, Hamid R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jasielec, Mateusz S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, Niklas K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graeber, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foerster, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Sarnowski, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danek, AdrianUNSPECIFIEDorcid.org/0000-0001-8857-5383UNSPECIFIED
Jucker, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bateman, Randall J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buckles, VirginiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saykin, Andrew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martins, Ralph N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, John C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-418428
DOI: 10.1155/2015/828120
Journal or Publication Title: Biomed Res. Int.
Volume: 2015
Date: 2015
Publisher: HINDAWI LTD
Place of Publication: LONDON
ISSN: 2314-6141
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; NATIONAL INSTITUTE; DEMENTIA; RECOMMENDATIONS; GUIDELINES; DECLINEMultiple languages
Biotechnology & Applied Microbiology; Medicine, Research & ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41842

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