Universität zu Köln

Kaspar, Daniela, Linder, Joerg, Zoellner, Petra, Simon, Ulrich and Smola, Hans (2015). Economic benefit of a polyacrylate-based hydrogel compared to an amorphous hydrogel in wound bed preparation of venous leg ulcers. CHRONIC WOUND CARE MANAG. RES., 2. S. 63 - 71. ALBANY: DOVE MEDICAL PRESS LTD. ISSN 2324-481X

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Abstract

Objective: To assess the cost-effectiveness of a polyacrylate (PA)-based hydrogel compared to an amorphous hydrogel in wound bed preparation for venous leg ulcers. Method: A cost-effectiveness analysis was undertaken alongside a multicenter, randomized controlled trial performed in France. A total of 75 patients with venous leg ulcers extensively covered with fibrin and necrotic tissue were randomized to a PA-containing hydrogel or an amorphous hydrogel. Wounds were treated for 14 days and costs were estimated from the - German payer's perspective. Medical costs included study treatment, wound treatment - supply, and labor time. The clinical benefit was expressed as the number of patients with wounds.50% covered with granulation tissue within 14 days. The incremental cost-effectiveness ratio (ICER) was expressed as the additional cost spent with >50% granulation tissue per day per patient within 14 days of leg ulcer care. Results: Because of individual pricing of wound dressings in hospitals, cost data were derived from the outpatient sector. A total of 33 patients were treated using the PA-based hydrogel and 37 patients using the amorphous hydrogel. The estimated total direct costs per patient and per 14 days of therapy were (SIC)306 for both treatment groups. However, with the PA-based hydrogel, 2.5 additional days with wounds covered.50% with granulation tissues were gained within 14 days of leg ulcer care compared to the comparator. The ICER was (SIC)0 per additional day spent with >50% granulation tissue. Conclusion: Although there were a greater number of dressing changes in the PA-based hydrogel treatment, the total treatment cost for 14 days of leg ulcer care was the same for both the PA-based-hydrogel and amorphous-hydrogel treatment modalities. The cost benefit favored the PA-based hydrogel because of its greater clinical efficiency in producing a viable wound bed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kaspar, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Linder, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoellner, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Smola, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-418495
DOI:	10.2147/CWCMR.S78580
Journal or Publication Title:	CHRONIC WOUND CARE MANAG. RES.
Volume:	2
Page Range:	S. 63 - 71
Date:	2015
Publisher:	DOVE MEDICAL PRESS LTD
Place of Publication:	ALBANY
ISSN:	2324-481X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Health Care Sciences & Services Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41849