Universität zu Köln

Meiberth, Dix, Scheef, Lukas, Wolfsgruber, Steffen, Boecker, Henning, Block, Wolfgang, Traeber, Frank, Erk, Susanne, Heneka, Michael T., Jacobi, Heike, Spottke, Annika, Walter, Henrik ORCID: 0000-0002-9403-6121, Wagner, Michael ORCID: 0000-0003-2589-6440, Hu, Xiaochen and Jessen, Frank (2015). Cortical Thinning in Individuals with Subjective Memory Impairment. J. Alzheimers Dis., 45 (1). S. 139 - 147. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Elderly individuals with subjective memory impairment (SMI) report memory worsening, but perform within the age-, gender-, and education-adjusted normal range on neuropsychological tests. Longitudinal studies indicate SMI as a risk factor or early sign of Alzheimer's disease (AD). There is increasing evidence from neuroimaging that at the group level, subjects with SMI display evidence of AD related pathology. This study aimed to determine differences in cortical thickness between individuals with SMI and healthy control subjects (CO) using the FreeSurfer environment. 110 participants (41 SMI/69 CO) underwent structural 3D-T1 MR imaging. Cortical thickness values were compared between groups in predefined AD-related brain regions of the medial temporal lobe, namely the bilateral entorhinal cortex and bilateral parahippocampal cortex. Cortical thickness reduction was observed in the SMI group compared to controls in the left entorhinal cortex (p = 0.003). We interpret our findings as evidence of early AD-related brain changes in persons with SMI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meiberth, Dix UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheef, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Boecker, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Block, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Traeber, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Erk, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneka, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jacobi, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Henrik UNSPECIFIED orcid.org/0000-0002-9403-6121 UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Hu, Xiaochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-419092
DOI:	10.3233/JAD-142322
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	45
Number:	1
Page Range:	S. 139 - 147
Date:	2015
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; HUMAN CEREBRAL-CORTEX; ALZHEIMERS-DISEASE; MATTER ATROPHY; THICKNESS; MRI; VOLUME; RELIABILITY; COMPLAINTS; SEVERITY Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41909