Universität zu Köln

Eming, Sabine A., Martin, Paul ORCID: 0000-0002-2665-5086 and Tomic-Canic, Marjana (2014). Wound repair and regeneration: Mechanisms, signaling, and translation. Sci. Transl. Med., 6 (265). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1946-6242

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Abstract

The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eming, Sabine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Paul UNSPECIFIED orcid.org/0000-0002-2665-5086 UNSPECIFIED Tomic-Canic, Marjana UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-420930
DOI:	10.1126/scitranslmed.3009337
Journal or Publication Title:	Sci. Transl. Med.
Volume:	6
Number:	265
Date:	2014
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	1946-6242
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; MIGRATION IN-VITRO; EXTRACELLULAR-MATRIX; LOWER-EXTREMITY; HAIR FOLLICLE; INFLAMMATORY RESPONSE; CUTANEOUS WOUNDS; TISSUE-REPAIR; VENOUS ULCERS Multiple languages Cell Biology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42093