Universität zu Köln

Merkle, J., Kohlhas, L., Zadoyan, G., Moesges, R. and Hellmich, M. (2014). Rhinomanometric reference intervals for normal total nasal airflow resistance. Rhinology, 52 (4). S. 292 - 300. UTRECHT: INT RHINOLOGIC SOC. ISSN 0300-0729

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Abstract

Background: Reference intervals (Rls) or mean values for normal total nasal airflow resistance are essential for the diagnosis of nasal obstruction. Data relating to nasal airflow are not standardised, and valid and reliable Rls do not exist for the time being. This meta-analysis aimed to determine such standard95%-Rls. Methodology: Research of related literature listed in Medline, Embase, Cochrane, and Web of Science databases. Results: Airflow resistance data were gathered from 38 studies using active anterior rhinomanometry at a differential pressure of 150Pa to examine patients under congested and decongested mucosal conditions. In the meta-analysis overall values and Rls for normal total nasal airflow resistance under congested nasal mucosal conditions were calculated for all subjects at 0.25Pa/ cm(3)/s (95%-RI 0.10-0.40Pa/cm(3)/s), adults regardless of gender at 0.25Pa/cm(3)/s (95%-RI 0.12-0.38Pa/cm(3)/s), men at 0.24Pa/cm(3)/s (95%-RI 0.09-0.39Pa/cm(3)/s), and women at 0.26Pa/cm(3)/s (95%-RI 0.08-0.44Pa/cm(3)/s). Asian, African and Caucasian ethnic groups exhibited rising airflow resistance mean values: 0.23Pa/cm(3)/s (95%-RI 0.08-0.39Pa/cm(3)/s), 0.25Pa/cm(3)/s (95%-RI 0.11-0.38Pa/cm(3)/s) and 0.26Pa/cm(3)/s (95%-RI 0.13-0.38Pa/cm(3)/s), respectively. Lower overall mean values resulted under decongested nasal mucosal conditions. Conclusion:The reference intervals and mean values ascertained in this meta-analysis improve the diagnosis of nasal obstruction and may represent a useful supplement in existing guidelines for the standardisation of rhinomanometric measurements.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Merkle, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohlhas, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zadoyan, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesges, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-421355
DOI:	10.4193/Rhino13.220
Journal or Publication Title:	Rhinology
Volume:	52
Number:	4
Page Range:	S. 292 - 300
Date:	2014
Publisher:	INT RHINOLOGIC SOC
Place of Publication:	UTRECHT
ISSN:	0300-0729
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVE ANTERIOR RHINOMANOMETRY; AGE-RELATED-CHANGES; INSPIRATORY FLOW; VALUES; OBSTRUCTION; POPULATION; CHILDREN; PATENCY Multiple languages Otorhinolaryngology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42135