Universität zu Köln

Herden, J., Ernstmann, N., Schnell, D. and Weissbach, L. (2014). The HAROW study: an example of outcomes research. A prospective, non-interventional study comparing treatment options in localized prostate cancer. Urologe, 53 (12). S. 1743 - 1752. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0563

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Abstract

The HAROW study was initiated to investigate the provision of ongoing medical care for patients with localized prostate cancer in a prospective, noninterventional setting and to investigate treatment options (Hormonal treatment, Active surveillance, Radiotherapy, Operation, Watchful waiting) under real-life conditions. A total of 3169 patients were enrolled by 259 participating physicians in private practice in Germany. The median follow-up was 28.4 months. At 6-month intervals, the treating physicians reported data on clinical parameters, clinical course of disease, and quality of patient-physician interaction. The highest proportion of patients with low risk tumor was found in the defensive treatment groups (AS and WW). As expected, the AS group showed the highest progression rate. In all, 112 AS patients (23.9%) changed therapeutic strategy, 21 of them upon medical advice in the absence of any signs of progression. Metastases were seen most frequently in the WW group (1.5%). No metastases occurred in AS patients. Medical support in managing the disease reached high scores in all groups, the highest in AS. The data enable a differentiated comparative analysis of patient and tumor characteristics of each treatment group. Indication of AS was predominantly consistent with the guideline. The high rate of AS termination based on the physician's recommendation rather than on clinical progression is remarkable, and may be interpreted as a kind of insecurity in dealing with AS. Results regarding communication indicate that patients appreciated being involved in treatment decisions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herden, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernstmann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnell, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weissbach, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-421516
DOI:	10.1007/s00120-014-3705-z
Journal or Publication Title:	Urologe
Volume:	53
Number:	12
Page Range:	S. 1743 - 1752
Date:	2014
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0563
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVE SURVEILLANCE; RADICAL PROSTATECTOMY; MORBIDITY Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42151