Universität zu Köln

Haeusler, Rainer E., Ludewig, Frank and Krueger, Stephan ORCID: 0000-0002-1658-5993 (2014). Amino acids - A life between metabolism and signaling. Plant Sci., 229. S. 225 - 238. CLARE: ELSEVIER IRELAND LTD. ISSN 0168-9452

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Abstract

Amino acids serve as constituents of proteins, precursors for anabolism, and, in some cases, as signaling molecules in mammalians and plants. This review is focused on new insights, or speculations, on signaling functions of serine, gamma-aminobutyric acid (GABA) and phenylalanine-derived phenylpropanoids. Serine acts as signal in brain tissue and mammalian cancer cells. In plants, de novo serine biosynthesis is also highly active in fast growing tissues such as meristems, suggesting a similar role of serine as in mammalians. GABA functions as inhibitory neurotransmitter in the brain. In plants, GABA is also abundant and seems to be involved in sexual reproduction, cell elongation, patterning and cell identity. The aromatic amino acids phenylalanine, tyrosine, and tryptophan are precursors for the production of secondary plant products. Besides their pharmaceutical value, lignans, neolignans and hydroxycinnamic acid amides (HCAA) deriving from phenylpropanoid metabolism and, in the case of HCAA, also from arginine have been shown to fulfill signaling functions or are involved in the response to biotic and abiotic stress. Although some basics on phenylpropanoid-derived signaling have been described, little is known on recognition- or signal transduction mechanisms. In general, mutant- and transgenic approaches will be helpful to elucidate the mechanistic basis of metabolite signaling. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haeusler, Rainer E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ludewig, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Krueger, Stephan UNSPECIFIED orcid.org/0000-0002-1658-5993 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-421894
DOI:	10.1016/j.plantsci.2014.09.011
Journal or Publication Title:	Plant Sci.
Volume:	229
Page Range:	S. 225 - 238
Date:	2014
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	0168-9452
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Botanical Institute
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GAMMA-AMINOBUTYRIC-ACID; SUCCINIC-SEMIALDEHYDE-DEHYDROGENASE; POLLEN-TUBE GROWTH; ARABIDOPSIS-THALIANA; GLUTAMATE-RECEPTOR; TRANSGENIC TOBACCO; CELL-DIVISION; AGROBACTERIUM-TUMEFACIENS; PSEUDOMONAS-SYRINGAE; SHIKIMATE PATHWAY Multiple languages Biochemistry & Molecular Biology; Plant Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/42189