Universität zu Köln

Caramoy, Albert, Ristau, Tina, Lechanteur, Yara T., Ersoy, Lebriz, Mueller, Sebastian, Gelisken, Faik, Hoyng, Carel B., Kirchhof, Bernd, den Hollander, Anneke I. and Fauser, Sascha (2014). Environmental and genetic risk factors for retinal angiomatous proliferation. Acta Ophthalmol., 92 (8). S. 745 - 749. HOBOKEN: WILEY-BLACKWELL. ISSN 1755-3768

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Abstract

PurposeTo identify genetic and environmental risk factors in patients with retinal angiomatous proliferation (RAP), a clinical subtype of age-related macular degeneration (AMD). MethodsIn this case-control study, 108 AMD cases with RAP, 258 AMD patients with choroidal neovascularization (CNV) without RAP and 443 healthy controls were evaluated. Single nucleotide polymorphisms in age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) and various environmental risk factors were analysed. Statistical analysis was performed by univariate and multivariate regression analysis. ResultsHigh age, female sex and genetic variants in CFH and ARMS2 were identified as risk factors for developing any CNV. In RAP patients, arterial hypertension was also identified as a risk factor (OR 2.39; p=0.0005). Compared with the non-RAP' CNV group, the association with high age (OR 1.05; p=0.008) and arterial hypertension (OR 1.82; p=0.02) was significantly higher in RAP patients, while the association with CFH risk alleles (homozygous OR 0.40; p=0.003) was significantly lower, which was confirmed in a multivariate analysis (OR 0.41; p=0.03 for the heterozygous risk allele and OR 0.38; p=0.03 for the homozygous risk allele). ConclusionThe association with the CFH Y402 risk allele was less pronounced in RAP patients than in non-RAP' CNV patients, while the association with high age and arterial hypertension appeared to be stronger. These findings stress the importance of detailed phenotyping in AMD to identify homogeneous AMD subtypes and their different risk factors and disease mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Caramoy, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Ristau, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Lechanteur, Yara T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ersoy, Lebriz UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Gelisken, Faik UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED den Hollander, Anneke I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422039
DOI:	10.1111/aos.12437
Journal or Publication Title:	Acta Ophthalmol.
Volume:	92
Number:	8
Page Range:	S. 745 - 749
Date:	2014
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1755-3768
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MACULAR DEGENERATION; AGE; POLYMORPHISM; METAANALYSIS; ASSOCIATION Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42203