Universität zu Köln

Vilchez, David ORCID: 0000-0002-0801-0743, Saez, Isabel and Dillin, Andrew (2014). The role of protein clearance mechanisms in organismal ageing and age-related diseases. Nat. Commun., 5. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

The ability to maintain a functional proteome, or proteostasis, declines during the ageing process. Damaged and misfolded proteins accumulate with age, impairing cell function and tissue homeostasis. The accumulation of damaged proteins contributes to multiple age-related diseases such as Alzheimer's, Parkinson's or Huntington's disease. Damaged proteins are degraded by the ubiquitin-proteasome system or through autophagy-lysosome, key components of the proteostasis network. Modulation of either proteasome activity or autophagic-lysosomal potential extends lifespan and protects organisms from symptoms associated with proteostasis disorders, suggesting that protein clearance mechanisms are directly linked to ageing and age-associated diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vilchez, David UNSPECIFIED orcid.org/0000-0002-0801-0743 UNSPECIFIED Saez, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Dillin, Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422712
DOI:	10.1038/ncomms6659
Journal or Publication Title:	Nat. Commun.
Volume:	5
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UBIQUITIN-PROTEASOME SYSTEM; CHAPERONE-MEDIATED AUTOPHAGY; BETA-AMYLOID PEPTIDE; LIFE-SPAN EXTENSION; ALPHA-SYNUCLEIN; CAENORHABDITIS-ELEGANS; OXIDATIVE STRESS; DIETARY RESTRICTION; DAMAGED PROTEINS; GENE-EXPRESSION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42271