Universität zu Köln

Pandey, Gaurav Kumar, Mitra, Sanhita, Subhash, Santhilal ORCID: 0000-0002-0077-4597, Hertwig, Falk ORCID: 0000-0003-4784-6516, Kanduri, Meena, Mishra, Kankadeb, Fransson, Susanne ORCID: 0000-0002-9713-3074, Ganeshram, Abiarchana, Mondal, Tanmoy, Bandaru, Sashidhar, Ostensson, Malin, Akyurek, Levent M., Abrahamsson, Jonas ORCID: 0000-0002-9240-3522, Pfeifer, Susan, Larsson, Erik, Shi, Leming ORCID: 0000-0002-7143-2033, Peng, Zhiyu, Fischer, Matthias, Martinsson, Tommy ORCID: 0000-0002-9403-3123, Hedborg, Fredrik, Kogner, Per ORCID: 0000-0002-2202-9694 and Kanduri, Chandrasekhar ORCID: 0000-0001-6271-9078 (2014). The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation. Cancer Cell, 26 (5). S. 722 - 738. CAMBRIDGE: CELL PRESS. ISSN 1878-3686

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Abstract

Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptonnes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. Thus, loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pandey, Gaurav Kumar UNSPECIFIED UNSPECIFIED UNSPECIFIED Mitra, Sanhita UNSPECIFIED UNSPECIFIED UNSPECIFIED Subhash, Santhilal UNSPECIFIED orcid.org/0000-0002-0077-4597 UNSPECIFIED Hertwig, Falk UNSPECIFIED orcid.org/0000-0003-4784-6516 UNSPECIFIED Kanduri, Meena UNSPECIFIED UNSPECIFIED UNSPECIFIED Mishra, Kankadeb UNSPECIFIED UNSPECIFIED UNSPECIFIED Fransson, Susanne UNSPECIFIED orcid.org/0000-0002-9713-3074 UNSPECIFIED Ganeshram, Abiarchana UNSPECIFIED UNSPECIFIED UNSPECIFIED Mondal, Tanmoy UNSPECIFIED UNSPECIFIED UNSPECIFIED Bandaru, Sashidhar UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostensson, Malin UNSPECIFIED UNSPECIFIED UNSPECIFIED Akyurek, Levent M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Abrahamsson, Jonas UNSPECIFIED orcid.org/0000-0002-9240-3522 UNSPECIFIED Pfeifer, Susan UNSPECIFIED UNSPECIFIED UNSPECIFIED Larsson, Erik UNSPECIFIED UNSPECIFIED UNSPECIFIED Shi, Leming UNSPECIFIED orcid.org/0000-0002-7143-2033 UNSPECIFIED Peng, Zhiyu UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinsson, Tommy UNSPECIFIED orcid.org/0000-0002-9403-3123 UNSPECIFIED Hedborg, Fredrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Kogner, Per UNSPECIFIED orcid.org/0000-0002-2202-9694 UNSPECIFIED Kanduri, Chandrasekhar UNSPECIFIED orcid.org/0000-0001-6271-9078 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-423485
DOI:	10.1016/j.ccell.2014.09.014
Journal or Publication Title:	Cancer Cell
Volume:	26
Number:	5
Page Range:	S. 722 - 738
Date:	2014
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1878-3686
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATING MUTATIONS; GENE-EXPRESSION; OVARIAN-CANCER; ALK KINASE; DISEASE; TUMORS; AMPLIFICATION; REGRESSION; DELETIONS; RECEPTOR Multiple languages Oncology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42348