Rizzoli, R., Branco, J., Brandi, M-L., Boonen, S., Bruyere, O., Cacoub, P., Cooper, C., Diez-Perez, A., Duder, J., Fielding, R. A., Harvey, N. C., Hiligsmann, M., Kanis, J. A., Petermans, J., Ringe, J. D., Tsouderos, Y., Weinman, J. and Reginster, J-Y. (2014). Management of osteoporosis of the oldest old. Osteoporosis Int., 25 (11). S. 2507 - 2530. LONDON: SPRINGER LONDON LTD. ISSN 1433-2965

Full text not available from this repository.

Abstract

This consensus article reviews the diagnosis and treatment of osteoporosis in geriatric populations. Specifically, it reviews the risk assessment and intervention thresholds, the impact of nutritional deficiencies, fall prevention strategies, pharmacological treatments and their safety considerations, the risks of sub-optimal treatment adherence and strategies for its improvement. This consensus article reviews the therapeutic strategies and management options for the treatment of osteoporosis of the oldest old. This vulnerable segment (persons over 80 years of age) stands to gain substantially from effective anti-osteoporosis treatment, but the under-prescription of these treatments is frequent. This report is the result of an ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis) expert working group, which explores some of the reasons for this and presents the arguments to counter these beliefs. The risk assessment of older individuals is briefly reviewed along with the differences between some intervention guidelines. The current evidence on the impact of nutritional deficiencies (i.e. calcium, protein and vitamin D) is presented, as are strategies to prevent falls. One possible reason for the under-prescription of pharmacological treatments for osteoporosis in the oldest old is the perception that anti-fracture efficacy requires long-term treatment. However, a review of the data shows convincing anti-fracture efficacy already by 12 months. The safety profiles of these pharmacological agents are generally satisfactory in this patient segment provided a few precautions are followed. These patients should be considered for particular consultation/follow-up procedures in the effort to convince on the benefits of treatment and to allay fears of adverse drug reactions, since poor adherence is a major problem for the success of a strategy for osteoporosis and limits cost-effectiveness.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rizzoli, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Branco, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandi, M-L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boonen, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruyere, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cacoub, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cooper, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diez-Perez, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duder, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fielding, R. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harvey, N. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hiligsmann, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kanis, J. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petermans, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ringe, J. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsouderos, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinman, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reginster, J-Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-425312
DOI: 10.1007/s00198-014-2755-9
Journal or Publication Title: Osteoporosis Int.
Volume: 25
Number: 11
Page Range: S. 2507 - 2530
Date: 2014
Publisher: SPRINGER LONDON LTD
Place of Publication: LONDON
ISSN: 1433-2965
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BONE-MINERAL DENSITY; CLINICAL VERTEBRAL FRACTURES; SERUM 25-HYDROXYVITAMIN D; POSTMENOPAUSAL WOMEN; VITAMIN-D; ZOLEDRONIC ACID; HIP FRACTURE; STRONTIUM RANELATE; VENOUS THROMBOEMBOLISM; NONVERTEBRAL FRACTURESMultiple languages
Endocrinology & MetabolismMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/42531

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item