Universität zu Köln

Freed, Brian ORCID: 0000-0002-4330-3488, Assall, Oliver Paul, Panagiotakis, Gary, Bang, Heejung, Park, Jongbae J., Moroz, Alex ORCID: 0000-0002-3502-3697 and Baethge, Christopher (2014). Assessing blinding in trials of psychiatric disorders: A meta-analysis based on blinding index. Psychiatry Res., 219 (2). S. 241 - 248. CLARE: ELSEVIER IRELAND LTD. ISSN 0165-1781

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Abstract

The assessment of blinding in RCTs is rarely performed. Currently most studies that do report data on evaluation of blinding merely report percentages of correct guessing, not taking into account correct guessing by chance. Blinding assessment using the blinding index (BI) has never been performed in a systematic review on studies of major psychiatric disorders. This study is a systematic review of psychiatric randomized control trials using the BI as a chance-corrected measurement of blinding, a tool to analyze and understand the patterns of blinding across studies of major psychiatric disorders with available data. Of 2467 psychiatric RD's from 2000 to 2010, 66 reported on blinding and 40 studies were found to have enough information on evaluation of blinding to be analyzed using the BI. The experimental treatment groups had an average BI value of 0.14 and the control groups had an average BI value of 0.00. The most common BI scenario was random random, indicating ideal blinding. A positive correlation between effect size and more correct guesses was also found. Overall, based on BI values and the most common blinding scenario, the published articles on major psychiatric disorders from 2000 to 2010, which reported on blinding assessment for patients, were effectively blinded. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Freed, Brian UNSPECIFIED orcid.org/0000-0002-4330-3488 UNSPECIFIED Assall, Oliver Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Panagiotakis, Gary UNSPECIFIED UNSPECIFIED UNSPECIFIED Bang, Heejung UNSPECIFIED UNSPECIFIED UNSPECIFIED Park, Jongbae J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moroz, Alex UNSPECIFIED orcid.org/0000-0002-3502-3697 UNSPECIFIED Baethge, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-425456
DOI:	10.1016/j.psychres.2014.05.023
Journal or Publication Title:	Psychiatry Res.
Volume:	219
Number:	2
Page Range:	S. 241 - 248
Date:	2014
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	0165-1781
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RANDOMIZED CONTROLLED-TRIALS; CLINICAL-TRIALS; QUALITY; STATEMENT; SUCCESS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42545