Universität zu Köln

Pedrosa, David J., Quatuor, Eva-Lotte, Reck, Christiane, Pauls, K. Amande M., Huber, Carlo A., Visser-Vandewalle, Veerle and Timmermann, Lars (2014). Thalamomuscular Coherence in Essential Tremor: Hen or Egg in the Emergence of Tremor? J. Neurosci., 34 (43). S. 14475 - 14484. WASHINGTON: SOC NEUROSCIENCE. ISSN 0270-6474

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Abstract

Thalamomuscular coherence in essential tremor (ET) has consistently been detected in numerous neurophysiological studies. Thereby, spatial properties of coherence indicate a differentiated, somatotopic organization; so far, however, little attention has been paid to temporal aspects of this interdependency. Further insight into the relationship between tremor onset and the onset of coherence could pave the way to more efficient deep brain stimulation (DBS) algorithms for tremor. We studied 10 severely affected ET patients (six females, four males) during surgery for DBS-electrode implantation and simultaneously recorded local field potentials (LFPs) and surface electromyographic signals (EMGs) from the extensor and flexor muscles of the contralateral forearm during its elevation. The temporal relationship between the onset of significant wavelet cross spectrum (WCS) and tremor onset was determined. Moreover, we examined the influence of electrode location within one recording depth on this latency and the coincidence of coherence and tremor for depths with strong overall coherence (tremor clusters) and those without. Data analysis revealed tremor onset occurring 220 +/- 460 ms before the start of significant LFP-EMG coherence. Furthermore, we could detect an anterolateral gradient of WCS onset within one recording depth. Finally, the coincidence of tremor and coherence was significantly higher in tremor clusters. We conclude that tremor onset precedes the beginning of coherence. Besides, within one recording depth there is a spread of the tremor signal. This reflects the importance of somatosensory feedback for ET and questions the suitability of thalamomuscular coherence as a biomarker for closed-loop DBS systems to prevent tremor emergence.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pedrosa, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Quatuor, Eva-Lotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Reck, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauls, K. Amande M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huber, Carlo A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-425588
DOI:	10.1523/JNEUROSCI.0087-14.2014
Journal or Publication Title:	J. Neurosci.
Volume:	34
Number:	43
Page Range:	S. 14475 - 14484
Date:	2014
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	0270-6474
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; PARKINSONIAN RESTING TREMOR; PATHOLOGICAL TREMORS; HUMAN THALAMUS; MOTOR CORTEX; CEREBELLAR; OSCILLATIONS; NETWORK; DISEASE; DELAY Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42558