Universität zu Köln

Richter, Nils, Allendorf, Inka, Onur, Oezguer A., Kracht, Lutz, Dietlein, Markus, Tittgemeyer, Marc, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Kukolja, Juraj ORCID: 0000-0003-1569-3287 (2014). The integrity of the cholinergic systemdetermines memory performance in healthy elderly. Neuroimage, 100. S. 481 - 489. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

Full text not available from this repository.

Abstract

The cholinergic system plays a central role in episodicmemory-related processes in health and disease. Cerebral acetylcholinesterase (AChE) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (PET) and [C-11] N-methyl-4-piperidyl acetate (MP4A). A close relationship between the kinetic constant k3 of MP4A and mnestic functions has been demonstrated for patients suffering from amnestic mild cognitive impairment and Alzheimer's disease. Under the hypothesis that AChE activity and memory are intimately linked in older age, we obtained MP4A-PET and structural magnetic resonance images aswell as neuropsychological data fromfourteen healthy older adults. Multiple regression analysis revealed that AChE activity in areas previously implicated in mnestic functions predicted episodic memory performance irrespective of cortical atrophy. Data suggest that in older adults the integrity of the cholinergic systemunderlies inter-individual variability in memory function. (C) 2014 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Richter, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Allendorf, Inka UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kracht, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Kukolja, Juraj UNSPECIFIED orcid.org/0000-0003-1569-3287 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-425768
DOI:	10.1016/j.neuroimage.2014.06.031
Journal or Publication Title:	Neuroimage
Volume:	100
Page Range:	S. 481 - 489
Date:	2014
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; ACETYLCHOLINE ESTERASE-ACTIVITY; MEDIAL TEMPORAL-LOBE; POSTERIOR CINGULATE CORTEX; FUNCTIONAL IMAGING DATA; ALZHEIMERS-DISEASE; EPISODIC MEMORY; PREFRONTAL CORTEX; NEURAL ACTIVITY; DECLARATIVE MEMORY Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42576